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43 Cards in this Set
- Front
- Back
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abl
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Oncogene
In CML. Codes for a non-receptor tyrosine kinase. |
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c-myc
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Oncogene
Burkitt's lymphoma Codes for a transcription factor. |
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bcl-2
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Oncogene
Follicular and undifferentiated lymphomas Codes for an anti-apoptotic. (This is why the undifferentiated cells stick around.) |
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erb-B2
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Oncogene
Breast, ovarian, and gastric carcinomas Codes for a tyrosine kinase |
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K-ras
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Oncogene
Colon carcinoma Codes for a GTPase |
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L-myc
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Oncogene
Lung tumor, especially small cell carcinoma. (Note the L in L-myc!) Codes for a transcription factor |
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N-myc
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Oncogene
Neuroblastoma - found in adrenal, not CNS! (Note the N in N-myc!) Codes for a transcription factor |
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ret
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Oncogene
MEN IIA & IIB (Multiple Endocrine Neoplasia) Codes for a tyrosine kinase |
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c-kit
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Oncogene
GIST (Gastrointestinal stromal tumor) Codes for a cytokine receptor |
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ret
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Oncogene
Medullary thyroid cancer MEN IIA & IIB (Multiple Endocrine Neoplasia - actually includes medullary thyroid cancer) Papillary thyroid cancer |
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Rb
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Tumor suppressor
Retinoblastoma, AND osteosarcoma Product blocks G1->S transition in cell cycle |
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p53
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Tumor suppressor
In most cancers & Li-Fraumeni syndrome Product blocks G1->S and G2->M transitions in cell cycle Mutation allows the cell to progress through the cycle despite mutations |
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BRCA1
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Tumor suppressor
Breast & ovarian cancers Product is a DNA repair protein |
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BRCA2
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Tumor suppressor
Breast cancer (tho only 3% have BRCA mutation) Product is a DNA repair protein |
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p16
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Tumor suppressor
Melanoma |
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APC
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Tumor suppressor
Colorectal cancer APC = Adenomatous Polyposis Coli Assoc w/FAP, Gardner's Syndrome, Turner's Syndrome |
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WT1
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Tumor suppressor
Wilms' tumor (WT - get it?) |
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NF1
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Tumor suppressor
Neurofibromatosis type 1 (easy enough) |
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NF2
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Tumor suppressor
Neurofibromatosis type 2 (easy enough) Causes bilateral acoustic schwanommas/neuromas |
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DPC
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Tumor suppressor
Pancreatic cancer DPC = Deleted in Pancreatic Cancer (not really, but it helps) |
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DCC
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Tumor suppressor
Colon cancer DCC = Deleted in Colon Cancer (not really, but it helps) |
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HTLV-1
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Human T-Lymphotrophic Virus (a retrovirus)
Adult T-cell leukemia/lymphoma |
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HBV, HCV
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Hepatitis B & C Viruses
Hepatocellular carcinoma HCV also assoc w/papillary thyroid carcinoma |
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EBV (4)
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Epstein-Barr Virus (herpes family)
Burkitt's lymphoma Hodgkin's lymphoma Nasopharyngeal carcinoma Oral hairy leukoplakia |
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HPV
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Human Papilloma Virus - specifically types 16 & 18
Genital carcinomas - most commonly cervical, but also penile/anal/vulvar |
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HHV-8
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Human Herpes Virus 8
Kaposi's sarcoma (esp with HIV-coinfection in gay males) Body cavity fluid B-cell lymphoma |
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HIV
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Human Immunodeficiency Virus
Primary CNS lymphoma |
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H. pylori
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Gastric adenocarcinoma
Lymphoma |
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Schistosoma haematobium
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Protozoan, not endemic to US
Squamous cell carcinoma of the bladder |
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Streptococcus bovis
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Colon cancer
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Clonorchis
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Protozoan, not endemic to US
Biliary cancer |
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Aflatoxins (produced by Aspergillus a fungus)
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Hepatocellular carcinoma
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Vinyl chloride
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Angiosarcoma
(blood vessel tumor occurring in liver) |
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CCl4
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Centrilobular necrosis & fatty change of the liver
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Nitrosamines (in smoked foods)
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Cancers of esophagus, stomach
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Cigarette smoke
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Squamous cell carcinoma of pretty much ANYTHING (larynx, lung, etc)
Renal cell carcinoma Transitional cell carcinoma of bladder |
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Asbestos
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Affects lung
Mesothelioma ALSO - bronchogenic carcinoma! |
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Arsenic
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Squamous cell carcinoma (of skin)
Angiosarcoma (blood vessel tumor in liver) |
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Naphthalene (aniline) dyes - in mothballs
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Transitional cell carcinoma of the bladder
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Alkylating agents (used in chemotherapy)
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Leukemias
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Radon
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Lung cancer
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BRAF
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Oncogene
Papillary thyroid cancer Product is a serine/threonine kinase |
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NTRK1
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Oncogene
Papillary thyroid cancer Product is constituently active tyrosine kinase |
