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8 Cards in this Set
- Front
- Back
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What is the difference between primary and secondary TIN?
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Primary is when the disease starts interstitially
Secondary is where the disease starts in the vascular or nephron itself. |
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What is a key clinical finding of TIN?
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Sterile pyuria and WBC casts
also will see a lack of proteinuria and hypoalbuminemia concentrating defect causing polyuria and nocturia RTA long term will see anemia |
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How does TIN present?
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abrupt onset renal dysfunction - polyuria, nocturia
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What is the classic triad of TIN?
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Rash, fever, eosinophilia
but only seen 30% of the time |
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What is the treatment of TIN?
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Remove offending drug
get a renal biopsy Corticosteroid with either prednisone or solumedrol |
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When does TIN classically appear?
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10-20 days after onset of drug therapy
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What will you find in the infiltrate in TIN?
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T-lymphocytes, monocytes, plasma cell, and eosinophils
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What does TIN look like on ultrasound?
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normal to enlarged kidneys with increased cortical echogenicity
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