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16 Cards in this Set
- Front
- Back
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which systemic diseases cause HSM?
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VIRAL, TYPHOID, BRUCELLOISIS, MELIOIDOSIS, LEPTOSPIROSIS, SYPHILIS, TUBERCULOSIS, ENDOCARDITIS, SYSTEMIC MYCOSES, CIRRHOSIS, VLM, KATAYAMA FEVER, LIVER FLUKE, TOXOPLASMOSIS, TOXINS
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WHAT IS HEPATOCELLULAR DAMAGE
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DIRECT EFFECT ON HEPATOCYTES(KILLS THEM)
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RESULTS OF HEPATOCELLULAR DAMAGE
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FAILURE OF FUNCTION EARLY
ELEVATED TRANSAMINASES JAUNDICE EVENTUALLY HYPOALBUMINEMIA - (edema/ascites) INC PROTHROBIN TIME (bleeding) |
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What is Biliary Obstruction and what are signs of it?
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IT IS CHOLESTASIS.
SIGNS ARE : Jaundice Elevated Alkaline phosphatase Intrahepatic - functional obstruction usually, Impaired excretion of bilirubin Extrahepatic - anatomic obstruction(gall stones, ie) |
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Describe portal system and problems
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Vascular congestion - here is where the gut is drained to clean things out....if blocked - portal hepatic
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WHAT ELSE CAN CAUSE LIVER DISEASE?
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MASS
NEOPLASMS PARASITES ABSCESS Bacterial Parasitic TRAUMA External Parasitic (eating liver - liver flukes CONGENITAL Cystic |
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CAUSES OF ACUTE HEPATIC FAILURE
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VIRAL EBV, CMV, HSV
HEP B,C,D,E COXSACKIE YF AND HEM PARASITIC FALCIP MALARIA BACTERIAL LEPTOSPIROSIS ENTERIC FEVER TICK BOURNE ANY SEVERE SEPSIS TOXINS, DRUGS, HERBALS, ALCOHOL |
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WHAT CAUSES JAUNDICE AND HEPATOMEGALY, USUALLY WITH FEVER
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MALARIA RICKETTSIAL - QFEVER
YF VIRAL HEP VLM KATAYAMA FEVER LIVER FLUKES BACTERIAL SEPSIS LEPTOSPIROSIS DRUG REACTIONS |
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WHAT CAUSES JAUNDICE AND HAPATOMEGALY WITHOUT FEVER
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CHRONIC (LATE) SCHISTO
NEOPLASMS TOXINS |
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DISCUSS PORTAL CONGESTION
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EDIT
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TENDER HEPATO W EOSINOPHILIA
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LIVER FLUKES, KATAYAMA FEVER, SERUM SICKNESS
EOSINOPHILIC MALIGNANCY |
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W/O EOSINOPHILIA - TENDER HEPATOMEG
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VIRAL HEP
AMEBIC ABSCESS PYOGENIC ABSCESS |
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MOST IMPORTANT SCHISTOSOMES
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MANSONI AND JAPONICUM FOR LIVER DISEASE
S HAEMATOBIUM FOR BLADDER |
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WHAT IS KATAYAMA FEVER
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ACUTE SSCHIISTO - independent of species
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DESCRIBE SYMPTOMS OF KATAYAMA
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SERUM LIKE ILLNESS
2-16 WEEK AFTER EXPOSURE may be before egg laying may be biphasic OTHER SYMPTOMS hepatosplenomegaly cough fever can be fatal |
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TREATMENT
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PRAZIQUANTEL, STEROIDS
(DX DUE TO ANTIGEN RELEASE, NOT PARASITES |
