Treatment Of Parkinson's Disease

Front 1

What is the MOA of Benztropine?

Back 1

Muscarinic cholinergic antagonist

*Balances dopaminergic-cholinergic systems by reducing cholinergic dominance

Front 2

What is the MOA of Diphenhydramine?

Back 2

Central muscarinic blockade

Front 3

What is the MOA of Levodopa?

Back 3

Immediate precursor of Dopamine that stimulate Dopamine synthesis in the brain.

Front 4

What is MOA of Levodopa in conjunction with Carbidopa?

Back 4

Carbidopa, a DOPA decarboxylase inhibitor, does not cross the BBB

Blocks the peripheral conversion of Levodopa to Dopamine resulting in:
1. dose of Levodopa can be decreased
2. n/v largely eliminated
3. cardiac side effects diminished
4. effective doses of Levodopa reached more quickly
5. antagonism of Levodopa's efficacy by Pyridoxine is avoided

Front 5

What is the MOA of Bromocroptine?

Back 5

Dopamine agonist with preference for the D2 subfamily of dopamine receptors

*Also treats hyperprolactinemia associated w/ secreting tumors of the anterior pituitary & with the use of dopamine antagonists such as antipsychotic drugs

Front 6

What is the MOA of Pramipexole?

Back 6

Non-ergot dopamine agonist

Specific for the D2 subfamily of dopamine receptors w/ higher affinity for the D3 receptor subtype

Front 7

What is the MOA of Selegiline?

Back 7

Irreversible MAO B inhibitors--slows the degradation of Dopamine

May have a neuroprotective effect

Front 8

What is the MOA of Entacapone?

Back 8

Elevates L-DOPA levels in the periphery by inhibiting COMT which metabolizes L-DOPA to 3-O-methyldopa

Front 9

What drugs are used to treat Tourette's Syndrome? What is their MOA?

Back 9

DOC--Haloperidol; MOA--dopamine receptor antagonist

Clonidine--alpha-adrenergic receptor agonist (pediatric population)

Front 10

How does Carbidopa alter the metabolism of L-DOPA?

Back 10

DOPA decarboxylase inhibitor that does not cross the BBB

Blocks the peripheral conversion of Levodopa to Dopamine