Use LEFT and RIGHT arrow keys to navigate between flashcards;
Use UP and DOWN arrow keys to flip the card;
H to show hint;
A reads text to speech;
10 Cards in this Set
- Front
- Back
What is the MOA of Benztropine?
|
Muscarinic cholinergic antagonist
*Balances dopaminergic-cholinergic systems by reducing cholinergic dominance |
|
What is the MOA of Diphenhydramine?
|
Central muscarinic blockade
|
|
What is the MOA of Levodopa?
|
Immediate precursor of Dopamine that stimulate Dopamine synthesis in the brain.
|
|
What is MOA of Levodopa in conjunction with Carbidopa?
|
Carbidopa, a DOPA decarboxylase inhibitor, does not cross the BBB
Blocks the peripheral conversion of Levodopa to Dopamine resulting in: 1. dose of Levodopa can be decreased 2. n/v largely eliminated 3. cardiac side effects diminished 4. effective doses of Levodopa reached more quickly 5. antagonism of Levodopa's efficacy by Pyridoxine is avoided |
|
What is the MOA of Bromocroptine?
|
Dopamine agonist with preference for the D2 subfamily of dopamine receptors
*Also treats hyperprolactinemia associated w/ secreting tumors of the anterior pituitary & with the use of dopamine antagonists such as antipsychotic drugs |
|
What is the MOA of Pramipexole?
|
Non-ergot dopamine agonist
Specific for the D2 subfamily of dopamine receptors w/ higher affinity for the D3 receptor subtype |
|
What is the MOA of Selegiline?
|
Irreversible MAO B inhibitors--slows the degradation of Dopamine
May have a neuroprotective effect |
|
What is the MOA of Entacapone?
|
Elevates L-DOPA levels in the periphery by inhibiting COMT which metabolizes L-DOPA to 3-O-methyldopa
|
|
What drugs are used to treat Tourette's Syndrome? What is their MOA?
|
DOC--Haloperidol; MOA--dopamine receptor antagonist
Clonidine--alpha-adrenergic receptor agonist (pediatric population) |
|
How does Carbidopa alter the metabolism of L-DOPA?
|
DOPA decarboxylase inhibitor that does not cross the BBB
Blocks the peripheral conversion of Levodopa to Dopamine |