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10 Cards in this Set
- Front
- Back
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Parkinson Disease |
Akinease/Bradykinesia Tremor Cogwheel rigidity Loss of Dopamine in SNrParsCompacta |
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Side Effects of L-Dopa |
Nausea- stimulation of dopamine in areas of postrema Hypotension- inhibits release of NE and decreases tone Arrythmias- stimualte dopa receptors Psychotic- activate dopamine in limbic system |
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Late Term Side Effects |
Dyskinesia- abnormal involuntary movements On-off phenomona- drug tolerance goes in and out Behaivoiral- depressino, anxiety |
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Carbidopa |
Blocks Decarboxylation of L-dopa |
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Rasagiline |
MAO B inhibitor prevents oxidation of L-Dope from oxidation in the brain may cause hypertension |
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Bromocriptine |
Dopamine Agonist stimulates dopamine receptors of striatum, reduces on-off symptoms Adverse: nausea, hypotension, delusions |
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Ropinirole Pramipexole Rotigone |
selective D2 receptor agonist monotherapy Adverse; same as L-Dopa |
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Benztropine |
muscarinic receptor antagonist blcoks muscarinic receptor of striatum, only useful late in disease adverse: dry mouth, blurred vision |
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Amatadine |
causes release of dopamine effective early causes hallucinations |
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Entacopone |
COMT prevents methylation of L-dopa by catechol-O-methyl transferase may cause liver damage |
