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10 Cards in this Set

  • Front
  • Back

Acetylcholinesterase

Enzyme that degrades the neurotransmitter acetylcholine

Alzheimer’s disease

Neurodegenerative disease that causes memory loss and behavioral changes

ApoE4 allele

Defective form of apolipoprotein E that is associated with Alzheimer’s disease

Tangles:

Twisted fibers made up of clumps of a protein called tau that interfere with nerve signal
transmission.

Nearly 5 million Americans and 500,000 Canadians have Alzheimer’s disease or disease-related
dementia.

Nearly 5 million Americans and 500,000 Canadians have Alzheimer’s disease or disease-related
dementia.

Acetylcholinesterase (AChE) is an enzyme that degrades acetylcholine (ACh).

Acetylcholinesterase (AChE) is an enzyme that degrades acetylcholine (ACh).

AChE inhibitors increase levels of ACh.

AChE inhibitors increase levels of ACh.

Three of the drugs approved for the treatment of Alzheimer’s disease are AChE inhibitors. They
are donepezil (Aricept), rivastigmine (Exelon), and galantamine (Reminyl).

Three of the drugs approved for the treatment of Alzheimer’s disease are AChE inhibitors. They
are donepezil (Aricept), rivastigmine (Exelon), and galantamine (Reminyl).

Memantine (Namenda) blocks the actions of glutamate at the NMDA receptor

Memantine (Namenda) blocks the actions of glutamate at the NMDA receptor

Plaques:

Substances composed of a protein called beta amyloid that fill the spaces between
neurons and interfere with the transmission of signals between neurons.