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22 Cards in this Set
- Front
- Back
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What is the use of AChEIs in the tx of AD? |
1. Tx of mild-to-moderate AD |
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What AChEIs are used to tx AD? |
1. Donepezil 2. Rivastigmine 3. Galatntamine |
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What are the adverse effects of donepezil? |
1. Bradycardia 2. Nausea 3. Diarrhea 4. Anorexia 5. Vivid dreams |
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With what can donepezil be combined to tx AD? |
1. Memantine |
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For patients with which symptoms can rivastigmine be effective? |
1. Delusions 2. Hallucinations |
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What is the MOA of rivastigmine? |
1. AChEI 2. Butylcholinesterase inhibitor |
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What is the warning associated with glantamine hydrobromide? |
1. People taking the drug had a higher death rate than those taking a placebo |
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What is the MAO of memantine? |
1. NMDA antagonist |
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What is the clinical indication of memantine? |
1. Moderate to severe AD |
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What are the adverse effects of memantine? |
1. Dizziness 2. HA 3. Confusion |
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What is first-line tx for MS? |
1. Prednisone 2. INF B 3. Glatiramer acetate (copaxone) |
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What is the use of glucocorticoids in the tx of MS? |
1. Acute attacks |
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What is the use of IFN B in the tx of MS? |
1. Reduce attacks 2. Patients with recurring-remitting MS |
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What is the MOA of IFN B? |
1. Inhibit T-cell proliferation 2. Restore BBB |
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What is the MOA of glatiramer acetate? |
1. Shift population of T cells from pro-inflammatory to regulatory |
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What is second-line tx for MS? |
1. Natalizumab 2. Mitoxantrone 3. Fingolimod 4. Teriflunomide |
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What is the MOA of natalizumab? |
1. Blocks VCAM-1 adhesion |
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What is the clinical use of mitoxantrone? |
1. Reduces relapse |
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What are the risks of mitoxantrone? |
1. Cardiotoxic 2. Increased risk of AML |
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What is the MOA of fingolimod? |
1. Prevents lymphocytes from entering circulation by binding S1P receptors |
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What is the MOA of teriflunomide? |
1. Blocks dihydroorotate DH |
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What is the MOA of dimethyl fumarate? |
1. Neuroprotective effects via NRF2 antioxidant pathway |
