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10 Cards in this Set

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Outward secretory pathway
ER --> Golgi Apparatus--> plasma membrane OR (via endosomes) --> lysosomes
Inward endocytic pathway
Extracellular molecules ingested from plasma membrane-->early endosomes--> late endosomes
Clathrin
protein coat molecules, clathrin -coated vesicles bud from Golgi and travel outward from secretory pathway.
From plasma-membrane, each vesicle starts off as clathrin-coated pit. Clathrin molecules assemble into a basket-like network on the cytosolic surface of the membrane.
Dynamin
Small GTP-binding protein that assembles as a ring around the neck of each deeply invaginated coated pit. Together with other proteins recruited to the neck of the vesicle, causes ring to constrict, pinching off the vesicle from the membrane
Adaptins
coat protein which secures the clathrin coat to the vesicle membrane and helps select cargo molecules for transport by trapping the cargo receptors that bind them.
Adaptin 1:
binds cargo receptors in the Golgi Apparatus
Adaptin 2
binds cargo receptors in the plasma membrane
COP-coated vesicles
(COP is coat protein) involved in transporting molecules between the ER and Golgi apparatus and from one part of the Golgi apparatus to another.
SNAREs
family of transmembrane proteins involved in recognition process. each organelle and each type of transport vesicle is believed to carry a unique SNARE and the interactions between complementary SNAREs help ensure that transport vesicles fuse only with correct membranes.
v-SNAREs--> snares on the vesicle recognized by
t-SNAREs-->on target membranes
What happens in the ER?
synthesis of most lip[ids, syntehesis of proteins for many (most) organelles and the plasma membrane, N-linked glycosylation of proteins (pre-assembled blocks of 14 sugars) with help of an enzyme, protein folding, disulfide bond formation