Transport Pathways

Front 1

Outward secretory pathway

Back 1

ER --> Golgi Apparatus--> plasma membrane OR (via endosomes) --> lysosomes

Front 2

Inward endocytic pathway

Back 2

Extracellular molecules ingested from plasma membrane-->early endosomes--> late endosomes

Front 3

Clathrin

Back 3

protein coat molecules, clathrin -coated vesicles bud from Golgi and travel outward from secretory pathway.
From plasma-membrane, each vesicle starts off as clathrin-coated pit. Clathrin molecules assemble into a basket-like network on the cytosolic surface of the membrane.

Front 4

Dynamin

Back 4

Small GTP-binding protein that assembles as a ring around the neck of each deeply invaginated coated pit. Together with other proteins recruited to the neck of the vesicle, causes ring to constrict, pinching off the vesicle from the membrane

Front 5

Adaptins

Back 5

coat protein which secures the clathrin coat to the vesicle membrane and helps select cargo molecules for transport by trapping the cargo receptors that bind them.

Front 6

Adaptin 1:

Back 6

binds cargo receptors in the Golgi Apparatus

Front 7

Adaptin 2

Back 7

binds cargo receptors in the plasma membrane

Front 8

COP-coated vesicles

Back 8

(COP is coat protein) involved in transporting molecules between the ER and Golgi apparatus and from one part of the Golgi apparatus to another.

Front 9

SNAREs

Back 9

family of transmembrane proteins involved in recognition process. each organelle and each type of transport vesicle is believed to carry a unique SNARE and the interactions between complementary SNAREs help ensure that transport vesicles fuse only with correct membranes.
v-SNAREs--> snares on the vesicle recognized by
t-SNAREs-->on target membranes

Front 10

What happens in the ER?

Back 10

synthesis of most lip[ids, syntehesis of proteins for many (most) organelles and the plasma membrane, N-linked glycosylation of proteins (pre-assembled blocks of 14 sugars) with help of an enzyme, protein folding, disulfide bond formation