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36 Cards in this Set

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active transport
uses energy to move solutes AGAINST their concentration gradient
uniport
only transport one substrate
symport
coupled transport of two substrates in same direction
antiport
coupled transport of two substrates in opposite direction
In active transport, shape change requires___
energy
Primary active transport
uses ATP as eneryg source-ATPases or pumps
Na+-K+-ATPase
primary active transport:
maintains the concentration gradients of Na+ and K+...3Na out to 2K in, 1 AtP..
source of potential energy
secondary active transport
couples energy of one molecule moving down its concentration gradient with another molecule moving against its concentration gradient.
can be symport or antiport
How is energy directed into the Na K ATPase?
3 na+ dependent phosphorylation, followed by 2K dependent dephosphorylation
membrane potential
difference in positive charges between the inside and outside of cell
pump stoichiometry of 3/2 is electrogenic
In an ion pump, Pi is transferred from ATP to the _____ forming a high energy anhydride linkage
carbyoxyl of a Glu or Asp residue..
later the phosphate is released by hydrolysis
ER Ca2+ pump is called
SERCA: sarcoendoplasmic reiculum Ca2+ ATPase
primary active transporter show substrate ___
saturation
Vmax
50% maxiaml rate at physiological substrate concentration
P-type
phosphorylation site
v-type
vacuole type for acidification of lysosomes, endosomes, golgi, and secretory vesicles
inner membrane ATPase to regulate H+ and adjust proton gradients is what type of transporter?
v-type
f-type
energy coupling factor. like ATP synthase
ABC transporter
ATP-binding Cassette protein for active transport of heavy metal ions and chemicals
indirect active transport
transporter uses a ion gradient that was caused by energy from a different transporter
ATPase creates
ion gradient
What is a Na-coupled D-glucose transporter?
secondary active symporter
NKCC
Na+/K+/2Cl- secondary symporter ...
reuptake of Na+ in kidney
Na+/H+ exchanger
secondary active antiporter
Na+/glucose cotransport
how does glucose go into the cell?
when the Na+ is released inside, it causes glucose release to inside
In a Na+/glucose cotransport, what stimulates glucose binding?
bound Na+
What are the 3 transport systems of calcium thru the membrane?
in:
Ca-channel

out:
Ca-ATPase

Ca-Na Antiport coupled with Na-K-ATPase
ouabain inhibits what?
na+-K+-ATPase

however, in low concentrations, ouabain can stimulate the transporter...therefore digoxin (Lanoxin) is used
Anion antiport in parietal cells of stomach with H+-K+-ATPase to produce what?
stomach acid - HCl is the product in the stomach luman
omeprazole inhibits what?
the H+-K+-ATPase directly
cimetidine
inhibits HK-ATPase activation by histamine receptor becaus it resembles a histamine
Secondary active transports allow substrates to move which way in respect to the gradient
UP or DOWN
secondary active transporters require what kind of energy?
concentrative-indirect input to move up the gradient
'loop' diuretics inhibit what?
NKCC
amiloride inhibits what?
Na/H antiport
electrochemical gradient is caused by
chemical force and electrical force