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10 Cards in this Set
- Front
- Back
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Prednisone & SoluMedrol - Action
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Corticosteroid. Suppresses inflammatory response; inhibits cytokine production & T-cell activation & proliferation.
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Prednisone & SoluMedrol - Side Effects
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Peptic ulcer, HTN, osteoporosis, Na & H2O retention, muscle weakness, easy bruising, delayed healing, hyperglycemia, risk for infection.
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Cyclosporine (Sandimmune, Neoral) - Action
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Calcineurin. Acts on T helper cells to prevent production and release of IL-2 & y-interferon; inhibits production of T cytotoxid lymphocytes & B cells.
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Cyclosporine (Sandimmune, Neoral) - Side Effects
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Nephrotoxicity, risk for infection, hepatotoxicity, lymphoma, HTN, tremors, hirsutism, leukopenia, gingival hyperplasia.
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Tacrolimus (Prograf) - Action
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Calcineurin. Same as cyclosporines but more effective.
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Tacrolimus (Prograf)- Side Effects
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Same as cyclosporines but more toxic.
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Cellcept - Action
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Cytotoxic Drugs. Inhibits purine synthesis; suppresses proliferation of T and B cells
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Cellcept - Side Effects
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DNV, severe neutropenia, thrombocytopenia, risk for infection, > incidence of malignancies.
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Rapamune - Action
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Cytotoxic Drugs. Suppresses T-cell activation & proliferation.
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Rapamune - Side Effects
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Risk for infection, hyperlipidemia, hypercholesterolemia, arthralgias, diarrhea, thrombocytopenia, > incidence of malignancies. Not used in liver or lung transplantation.
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