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15 Cards in this Set

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Choloramphenicol
Binds to peptidyl transferase region of larger ribosomal subunit and inhibits peptide bond formation, inhibits translation
Erythromycin
Binds near peptidyl transferase region and blocks exit of peptide
Tetracyclines
Bind to smaller subunit, interact with A site an affect biding of tRna
Aminoglycosides
Binds the decoding region of smaller subunit causing errors in reading mRNA, wrong amino acid is incorporated.
Essential Amino Acids
PVT TIM HALL
Phenylalanine, Valine, Threonine, Tryptophan, Methionine, Histidine, Arginine, Lysine, Leucine

Need Vitamin B6
Stop Codons
UAA, UGA, UAG
Silent Mutation
Alters codon, but same amino acid
Missense Mutation
Altered codon codes for different A.A.
Nonsense Mutation
Altered codon codes for stop codon.
Methionine
AUG triplent, Start Codon
Diphtheria Toxin from (Corynebacterium diphtheria)
Catalyzes ADP-riboslation of EF 2 and blocks protein synthesis.
Cholera and pertussis
Target GTP -regulation proteins
Ribosome Subunit Size
80s = 60s + 40s
Initiation
1. Components are assembled: mRNA, Aminoacyl tRNA, initiation factors (eIF)
2. GTP is energy source
3. Enter P site
Elongation/Termination
1. Ribosome moves 5'-3'
2. new tRNA docks at A site
3. Peptidyltransferase mediates formation of peptide bond
4. AA from P site is transferred to AA on A site
5. Ribosome advance 3 nucleotides in 3' direction
6. Release factor is recognized by termination codon