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15 Cards in this Set
- Front
- Back
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Choloramphenicol
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Binds to peptidyl transferase region of larger ribosomal subunit and inhibits peptide bond formation, inhibits translation
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Erythromycin
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Binds near peptidyl transferase region and blocks exit of peptide
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Tetracyclines
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Bind to smaller subunit, interact with A site an affect biding of tRna
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Aminoglycosides
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Binds the decoding region of smaller subunit causing errors in reading mRNA, wrong amino acid is incorporated.
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Essential Amino Acids
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PVT TIM HALL
Phenylalanine, Valine, Threonine, Tryptophan, Methionine, Histidine, Arginine, Lysine, Leucine Need Vitamin B6 |
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Stop Codons
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UAA, UGA, UAG
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Silent Mutation
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Alters codon, but same amino acid
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Missense Mutation
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Altered codon codes for different A.A.
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Nonsense Mutation
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Altered codon codes for stop codon.
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Methionine
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AUG triplent, Start Codon
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Diphtheria Toxin from (Corynebacterium diphtheria)
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Catalyzes ADP-riboslation of EF 2 and blocks protein synthesis.
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Cholera and pertussis
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Target GTP -regulation proteins
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Ribosome Subunit Size
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80s = 60s + 40s
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Initiation
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1. Components are assembled: mRNA, Aminoacyl tRNA, initiation factors (eIF)
2. GTP is energy source 3. Enter P site |
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Elongation/Termination
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1. Ribosome moves 5'-3'
2. new tRNA docks at A site 3. Peptidyltransferase mediates formation of peptide bond 4. AA from P site is transferred to AA on A site 5. Ribosome advance 3 nucleotides in 3' direction 6. Release factor is recognized by termination codon |
