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23 Cards in this Set
- Front
- Back
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What are the advantages of component separation?
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1) rbc and plasma can be given separately
2) specific products to specific needs 3) ideal storage conditions for each product 4) "stretches" products |
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What are the biochemical changes on storage?
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Incr: K and Hb in plasma
Decr: pH, ATP, 2,3-DPG, Na+, nitric oxide |
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What is the purpose of the following anti-coagulants?
Citrate, Phosphate, Dextrose, Adenine |
Citrate: chelating Ca2+
Phosphate: prevent drop in pH Dextrose: supports ATP generation Adenine: substrate for ATP production |
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When is additive added to the red cells?
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After plasma is removed
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Expiration.
CPD CPDA-1 CPD with additive (AS-3) CPD with SAGM |
CPD 21 days
CPDA-1 35 days CPD with additive (AS-3) 42 days CPD with SAGM 42 days |
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What is in the additive?
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Phosphate
Adenine Glucose Saline Citrate |
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Why do leukocyte reduction?
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1) reduce febrile rxns
2) reduces rate of CMV infection 3) reduces WBC count & cytokines |
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Why wash cells?
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reduce reactions to plasma proteins, esp pt with anti-IgA
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Why irradiate products?
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to prevent GVHD in immunodeficient pts
expiry date 28 or orginal expiry date |
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Where is the source for Fractionation products
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donor plasma
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3 types of fractionation products
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1) coagulation factor concentrates
2) immune globulins 3) Albumin |
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Types of immunoglobulin available
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1) Immune Serum Globulin (Hep A or measles)
2) Intravenous Immune Globulin (hypogammaaglobulinemia, ITP) 3) Rh Immune GLobulin (RhIg, for preg women) 4) Hep B Immune Globulin 5) Varicella-Zoster immune globulin (chicken pox) |
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Where is albumin from and use of it in human.
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1) Human source
2) volume replacement in acute hemorrhage 3) replacement of proteins in burn patients |
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What percent mix of albumin equals human plasma.
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5%
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How often does temp needs to be checked when storage and transport?
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every 4 hours
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Uses of Whole blood
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- volume replacement
- autologous blood |
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Uses of packed cells.
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- hemorrhage or anemia
- oncology pts, trauma, sx, renal dis, premature infants, sickle cell |
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Uses of Platelets
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- bleeding problems
- hemostasis |
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Uses of Fresh Frozen Plasma
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- coagulation factors
- management of bleeding - DIC |
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Uses of Frozen Plasma
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- contains stable coagulation factors only
- has reduced amts of factors V and VIII |
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Uses of Cryoprecipitate (a factor VIII)
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- contains factor VIII and fibrinogen
- treat pts with hemophilia or fibrinogen defects |
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Uses of granulocytes
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- to fight infections, esp infants who are septic
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Uses of Frozen Red Cells
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- rare cells
- autologous blood |
