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5 Cards in this Set

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Definition of HDN
Fetal cells coated with maternal IgG directed against of paternal origin and absent from maternal cells
HDN Physiological observations:
Erythroblastosis Fetalis
a.Erythroblastosis: accelerated red cell destruction simulated increased production of cells that enter circulation prematurely, hence the name.
HDN Physiologgical observations:
Hydrops Fetalis
Hydrops Fetalis:generalized edema; generalized erythropoesis resulting in COP,anemia,cardiovascular failure, tissue hypoxia.
HDN Physiological Observations:
In utero
Infant exhibits anemia and heart failure:
Bilirubin processed by mother's liver; At birth, infant liver is incapable of conjugating amounts of bilirubin that results; unconjugated bilirubin toxic to developng CNS.
HDN Physiological Observations:
1. Live born infant
2.Exchange transfusion:
unconjugated bilirubin may pose greater concern than anemia.
Exchange transfusion based on: Bilirubin level, rate of bilirubin accumulation, to a lesser degree, severity of anemia.