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20 Cards in this Set
- Front
- Back
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Make up 60-80% of lymphocytes; Rosette formation sRBC; CD2-4 and CD-8
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T-Cells
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Found in BM, Spleen, lymph nodes; Produce antibody. CD19-21 and CD40
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B-Cells
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CD4 is found on what cells
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Th cells, monocytes and macrophages
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CD8 is found on what cells
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Thymocyte subsets, cytotoxic T cells
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CD21 is found on what cells
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B cells (w/receptor for C3d)
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CD44 is found on what cells
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Most leukocytes (WBCs)
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What is the rationale behind irradiating blood
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To remove WBCs, so the self identifiers (MHC / HLA) on their surface would negatively affect a recipient
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Class 1 MHC Expression leads to what
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Alpha chain whose ligand is CD8 (borne by Tc)
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Class 2 MHC expression leads to what
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Alpha and beta chains whose ligand is CD4 (borne by Th)
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MHC 1 is expressed on what cells
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All nucleated cells, but highest on lymphocytes
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MHC 2 is expressed on what cells
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APCs, B cells, Monocytes and Macrophages, dendritic, endothelial
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1st Ig produced, longer half-life, pentamer, that can fix complement
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IgM
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Can cross placenta (good and bad thing) and can fix complement
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IgG
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Bis Jones in light chains are associated with what?
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Leukemia and multiple meyeloma (cancer that starts in the plasma cells in bone marrow)
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Binds HgB and is toxic; levels of this compound will go down during hemolytic episode
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Haptoglobin
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Genetic variations in C region of H and L chains; helps identify class of Ab
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Isotype
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Isotypes are made up of what two things
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2 Kappa or 2 lambda chains
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Where antigens bind to an Ab; there are two per Ig/Ag unit
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FAB Region (fragment antigen binding)
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Dictates biologic/effector fxn of an Ab; is secreted or membrane bound
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Fc Region (fragment crystalline)
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Receptor for chems secreted by blood cells during inflammation; receptor for P. Vivax, the RBC parasite causing malaria
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Duffy glycoprotein
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