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38 Cards in this Set
- Front
- Back
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What are the 3 most common transfusion reactions and what is the risk per unit transfused for each?
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Hives 1/100
Simple febrile rxn 1/200 TACO 1/700 |
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What is the risk per unit for:
-TRALI -DHTR -Bacterial sepsis from plts |
TRALI 1/5000
DHTR 1/7000 Bacterial sepsis 1/10000 |
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What are the risk of ABO incompatibility or anaphylaxis transfusion reactions?
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1/40,000
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What are the risk per unit for transfusions for HBV, HCV, and HIV?
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HBV 1/220,000
HCV and HIV 1/2,000,000 |
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So has blood transfusion really become that much safer?
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No not really
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What are the 3 most common transfusion reactions and what is the risk per unit transfused for each?
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Hives 1/100
Simple febrile rxn 1/200 TACO 1/700 |
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What is the risk per unit for:
-TRALI -DHTR -Bacterial sepsis from plts |
TRALI 1/5000
DHTR 1/7000 Bacterial sepsis 1/10000 |
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What are the risk of ABO incompatibility or anaphylaxis transfusion reactions?
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1/40,000
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What are the risk per unit for transfusions for HBV, HCV, and HIV?
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HBV 1/220,000
HCV and HIV 1/2,000,000 |
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So has blood transfusion really become that much safer?
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No not really
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What does pre-transfusion testing consist of?
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ABO and Rh typing
Ab screen Crossmatch |
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Shelf life of PRBC's in adsol is:
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42 days
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What is the Hct of PRBCs
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55-60%
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How much does 1 unit of PRBCs raise a patient's Hb?
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1 g/dl
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What's better; liberal, or restrictive transfusions?
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Restrictive - wait til the Hb is really low and warrants it.
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How much does one random donor unit of platelets raise a pt's plt count?
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1 random unit per 10 kg person raises it 50K
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What compatibility is important to remember when giving plts?
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Rh
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At what plt count is transfusion indicated in bone marrow failure patients?
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<10,000
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At what platelet counts should prophylactic transfusions be given for general surgery and procedures?
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<50,000
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At what platelet counts should prophylactic transfusions be given for Eye, CNS, and high risk surgeries?
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<100,000
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What type of blood product has the highest reported fatalities due to TRALI?
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FFP
then RBC, then, RBC+FFP |
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What is contained in FFP?
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-200-250 ml plasma
-All clotting factors -Anticoagulants (Prot S, C, antithrombin-III) |
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How long can FFP be stored?
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Frozen at 18'C up to 1 year
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What patients can receive:
A FFP B FFP AB FFP O FFP |
A - to A or O
B - to B or O O - to O AB - to anyone |
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What are 2 major categories of indications for FFP?
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-Replacement of plasma proteins for hemostasis
-Replacing fluid in therapeutic plasma exchange |
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What are 3 causes of multiple factor deficiency?
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-Liver disease
-Vit K defic -DIC |
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FFP is NOT indicated for:
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-Volume expansion
-Heparin reversal |
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For what INR/PT is FFP not really indicated?
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If it's only prolonged like 3sec, or the INR is <1.5
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In what patients will FFP never completely correct the PT?
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Chronic liver patients
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What is the usual dose of FFP?
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10 ml/kg patient
which is 3-4 units in the average adult |
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What's the takehome message about FFP given to ICU patients?
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It doesn't really decrease bleeding episodes, but has increased rates of TRALI
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What does Cryoppt contain?
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-Factor VIII
-Fibrinogen -vWF -Factor XIII -Fibronectin |
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What are 2 main indications for giving cryo?
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-Hypofibrinogenemia
-Dysfibrinogenemia |
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What are 3 causes of hypofibrinogenemia?
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-DIC
-Severe liver disease -Dilutional |
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What is the goal when giving cryo?
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To get the fibrinogen level above 150 mg/dl
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How is Cryo dosed?
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1 unit per 5kg body weight
(typical dose is 12 units) |
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When is cryo NOT indicated?
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Hemophilia A or vWD
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How much is in a bag of Cryo?
-Amount -Factor VIII -Fibrinogen |
30 CC per bag
80 units of Fx VIII 250 mg fibrinogen |
