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9 Cards in this Set
- Front
- Back
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What is the source of zinc toxicosis?
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-ingestion of zinc containing pennies
-accidental ingestion of excessive zinc from food and beverages -galvanized wire -plumbing nuts -batteries -zinc oxide ointment -overdose by dietary zinc supplements |
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What is the toxicity of zinc?
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acute LD 50 is about 100mg/kg
subacute toxicosis is caued by ingestion of about 5 pennies Chonic toxxicity can be caused by over 2000 ppm in diet |
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What is the toxicokinetics of zinc?
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acid environment enhances zinc release and absorption
2/3 bound to albumin accumulates in the pancreas, liver, kidney, spleen and male reporductive organs excreted in bile, saliva, sweat |
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What is the mechanism of action of zinc?
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unknown
irritant to GI mucosa may interfere with certain enzymes may cause direct damage to cell membrane and organelles interferes with coper and iron absorption causes hemolytic anemia |
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What are the signs of zinc toxicosis?
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vomiting, anorexia, lethargy, abdominal pain and pica
hemolytic anemia, icterys and hemoglobinuria lameness and stiffness are prominant in foals |
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What are the lesions associated with zinc?
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gastritis
gastric ulcers liver damage tubular casts |
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How do you laboratory diagnose zinc toxicosis?
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chemical analysis of the serum, liver, kidney and urine
hemolytic anemia, icterus and hemoglobinuria azotemia, hypercreatinemia and hyperphosphatemia decreased copper in liver in chronic toxicosis may see foreign objects on abdominal radiographs |
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What are differential diagnoses of zinc toxicosis?
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copper toxicosis
naphthalene toxicosis onion poisoning red maple cotton seed (gossypol) mustard poisoning IMHA hypophosphatemia phenolics DMSO Guaifenesin overdose |
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How do you treat zinc toxicosis?
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decontamination
-cathartics, surgical or endoscopic removal supportive care -blood transfusion -O2 -fluids -furosemide, mannitol or dopamine for acute renal failure Chelation - after correcting dehydration |
