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8 Cards in this Set
- Front
- Back
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What are rotenones?
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-an old insecticide used to kill fish
-use for ear mites in dogs cats and rabbits -more toxic by inhalation than ingestion |
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What is the mechanism of action of rotenone?
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-affects cellular respiration
-inhibits the oxidation of NADH to NAD -blocking the oxidation of NAD of substrates such as glutamate pyruvate |
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What are the acute clinical signs of rotenone toxicosis?
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-local irritation
-ingestion causes irritation of GI mucosa - vomiting -inhalation can cause respiratory convulsions and death |
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What are the signs of chronic signs of rotenone toxicosis?
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liver and kidney damage
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What are laboratory diagnoses or rotenone?
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chemical analysis of vomit, blood, urine or feces
May be hypoglycemic |
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How do you diagnose rotenone toxicosis?
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history
clinical signs lesions laboratory diagnosis |
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What is the treatment for rotenone toxicosis?
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no specific antidote
detoxification supportive care -diazepam or barbiturate for seizures -Dextrose IV for hypoglycemia |
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What is the prognosis of rotenone toxicosis?
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excellent
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