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18 Cards in this Set
- Front
- Back
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What is an example of a first generation anticoagulant?
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Warfarin
Pindone Chlorophacinone |
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What are examples of second generation anticoagulants?
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Brodifacoum
Bromodiolone Diphenadion more potent thank 1st generation |
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What species are the most susceptible to anticoagulant rodenticides?
Sensitive |
Dogs
Pigs |
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What is the toxicity of anticogulant rodenticides?
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Subacute take about 3-5 days to see clinical signs because it takes time to deplete clotting factors
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What factors increase toxicity of anticoagulant rodenticides?
decrease |
Vitamin K deficiency
anemia hemolysis pregnancy lactation enzyme inducers |
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What is the mechanism of action of anticoagulants in acute toxicosis?
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inhibition of vitamin K epoxide reductase
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What are the clotting factors required for vitamin K activation?
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II
VII IX X |
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Which clotting test would you run first in anticoagulant rodenticide toxicosis?
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-PT because it test factor VII in the extrinsic pathway and it has the shortest half life
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What is the antidote for anticoagulant rodenticide toxicosis in a stable patient?
unstable patient? |
vitamin K1
fresh frozen plasma |
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What rodenticides have acute toxicity?
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Vit D
Bromathalin Strychnine Zinc Phosphide Fluoracetate |
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What rodenticides have subacute or chronic toxicity?
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Anticoagulation rodenticides
bromethalin zinc phosphide |
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What rodenticides are dogs most sensitive to?
cats? Birds? Large animals? |
-Anticoag and strychnine
-Vit D, bromethalin, fluroacetate -Zinc phosphide -Strychnine and pigs to anticoag |
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What rodenticides are neonates more sensitive to?
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vitamin D
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What rodenticides are guinea pigs resistant to?
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Bromethalin
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Which two rodenticides have lethal synthesis?
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Vitamin D and bromethaline
*both significant in bile excretion |
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What rodenticides cause CNS excitement?
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Zinc phosphide
fluroacetate bromethalin strychnine |
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Which rodenticides cause hypercalcemia?
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Vitamine D toxicosis
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What rodenticides have elicitable seizures?
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bromethaline
strychnine zinc phosphide |
