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14 Cards in this Set
- Front
- Back
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Signs of cholinergic poisoning
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Salivation
Lactrimation Urination Defication Gastrointestinal cramping Emesis (vomiting) OR Ations: Salivation, Defication, Urination, Fasciculations Heas: Diarrhea, Bronchorrhea, Rhinorrhea, Bradycardia |
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Muscarinic poisoning can occur from?
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Organophosphates
Insecticides Nerve Gas (Serin) |
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Muscarinic poisoning would do what to your eyes?
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Constrict
Dilation = alpha1 |
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Action of organocphosphates:
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inhibit acetylcholinesterase (get excess AcH, which affects, M, N and CNS receptors)
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What symptoms do you have in Nicotinic poisonings that you wouldn't in muscarinic
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Fasciculations
Paralysis Tachycardia mydriasis (pupil dilation) |
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What odors are associated with organophosphate and cyanide poisoning?
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Garlic odor
Bitter almonds |
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Antidote for organophosphates is?
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Pralidoxamine: reduces AcH-Esterase phophorylation. This is critical to do quickly bc bond becomes covalent instead of ionic after a certain time
Atropine: Anticholinergic, blocks M receptors (increases heart rate, dries secretions and decrease bronchoconstriction) |
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Effect of antihistamine poisoning
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Similar to that of Anti-cholinergics:
dry mouth urinary retention constipation tachycardia dilated pupils hyperpyrexia (fever) (Can't see, can't spit, can't see, can't shit OR Hot, Dry, Tacky, Wacky) |
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Antidote for anticholinergics is:
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Physostigmine, blocks acetylcholinesterase so more competition for receptors. Contraindicated with wide QRS
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Antidote for anticholinergics is contraindicated when
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Wide QRS
Physostigmine |
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What receptors does meth work on? Presentation?
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B1 and Alpha one
Presentation: Increased HR (B1) Increased BP (alpha 1) Hyperthermia Apetite loss Pupil dilation |
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Difference between sympathamemetics and anticholinergics
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Anti: Can't sweat, dry mouth
Symp: Hypertension |
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Treatment for meth
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Benzos
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Beta blockers
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NE can't bind to B1 or B2
Lowers HR and BP and Glucose. Antidote is Glucagon (increase intracellular cAMP) |
