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Linear Energy Transfer (LET)
(α Particles) - energy loss moving though tissue - slower moving Vs faster moving particles - High LET to tissue creates - Levels of damage to DNA |
- Lose 10-20% of Energy traveling through10 cm tissue
- Slower moving α particles have > chance to interact with matter, so energy loss per unit distance is greater - ionization and dissociation in tissue -0.6 or 5.0 MeV α particle damages DNA. α particles can even cause a double-strand break; Mechanisms of damage: by direct production of ions (reactive chemical species) by ejection of electrons, which may have enough energy to produce further ionization. |
