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45 Cards in this Set
- Front
- Back
Dose Limiting Toxicity
Classic alkylators |
BMS (Main DLT)
sterility, secondary malignancies, teratogenicity |
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Dose Limiting Toxicity
Platinum analogues |
BMS, neurotoxicities
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Dose Limiting Toxicity
Nitrosureas |
cumulative and delated BMS, severe N/V
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Dose Limiting Toxicity
Antimetabolites |
Mucositis (Main DLT)
BMS, N/V |
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Dose Limiting Toxicity
Folate Antagonists |
BMS and mucositis (DLT)
hepatotoxicity, interstitial pneumonitis |
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Dose Limiting Toxicity
Purine Antagonists |
BMS, renal tubule damage (DLT)
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Dose Limiting Toxicity
Pyrimidine Antagonists and Cytidine Analogues |
BMS (DLT)
mucositis, diarrhea |
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Dose Limiting Toxicity
Topoisomerase I inhibitors |
BMS (Main DLT)
diarrhea (DLT for irinotecan) |
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Dose Limiting Toxicity
Topoisomerase II - Anthracyclines |
BMS and cardiac toxicity
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Dose Limiting Toxicity
Topoisomerase II - Epipodophyllotoxins |
BMS (DLT)
|
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Dose Limiting Toxicity
Taxanes |
BMS (DLT) cumulative neurotoxicity (paclitaxel)
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Dose Limiting Toxicity
LHRH agonists |
increase bone paine, tumor flair, hot flashes
|
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Dose Limiting Toxicity
estrogen receptor modulators |
menopausal symp., N/V, vag bleed, THROMBOTIC EVENTS
|
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Dose Limiting Toxicity
aromatase inhibitors |
N/V, hot flashes, tumor flair, wt gain
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Dose Limiting Toxicity
antiandrogens |
Diarrhea, gynecomastia, sex dysfunction, hematuria
|
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Dose Limiting Toxicity
Corticosteroids |
Hyperglycemia
|
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Dose Limiting Toxicity
Signal transductase inhibitors |
N/V/D, skin rash, dry skin
|
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Dose Limiting Toxicity
Monoclonal antibodies |
hypersensitivity reactions
|
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Dose Limiting Toxicity
Interferons |
Flu-like syndrome, progressive fatigue (DLT)
BMS |
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Dose Limiting Toxicity
Interleukins |
CV, GI, wt gain, neuologic, renal toxicities, rash
|
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Ifosfamide
|
Hemorrhagic cystitis
|
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Cyclofosphamide
|
Hemorrhagic cystitis, pulmonary fibrosis
cardiac toxicity, BMS |
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Busulfan
|
pulmonary fibrosis
|
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Cisplatin
|
Nephrotoxicity, some oto and neuro
|
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Carboplatin
|
BMS, neuropthaties
|
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Oxaliplatin
|
peripheral neuropathy, BMS
|
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Dacarbazine
|
lots of anticipatory N/V
|
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Cytarabine
|
cerebeller ataxia, conjunctivitis, hand-foot synd
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5-FU
|
ataxia, dermatologic toxicities, ophthalmic changes
|
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irinotecan and topotecan
|
fever/flu-like symp., elevated LFTs
|
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Anthrcyclines
|
vesicant, red urine, hand-foot syndrome
|
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Etoposide
|
HOTN (cremaphor vehicle), phlebitis, hypersensitivity
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Vincristine
|
Constipation, bowel paralysis
|
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Vinblastine
|
BMS
|
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Taxanes
|
Hypersensitivities, ?
|
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Ixabepilone
|
neutropenia, fatigue, hand-foot syndrome, diarrhea, neuropathy
|
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Bleomycin
|
pulmonary fibrosis @ >100-450U
|
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Hydroxyurea
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Hypersensitivity
|
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Imatinib
|
edema, skin rash, N/V/D
|
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Gefitinib
|
N/V/D, rash, acne, dry skin
|
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Cetuximab
|
severe infusion reactions, uricaria, HoTN, rash
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Bevacizumab
|
HTN, tiredness, diarrhea, impaired healing
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Thalidomide
|
neuropathy, constipation, rash, increase risk of DVT
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tretinoin
|
dry skin, HA, fever, ocular, liver, and lipase changes
|
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arsenic trioxide
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QT interval prolongation, fever, rash, edema, wt gain
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