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45 Cards in this Set

  • Front
  • Back
Dose Limiting Toxicity
Classic alkylators
BMS (Main DLT)
sterility, secondary malignancies, teratogenicity
Dose Limiting Toxicity
Platinum analogues
BMS, neurotoxicities
Dose Limiting Toxicity
Nitrosureas
cumulative and delated BMS, severe N/V
Dose Limiting Toxicity
Antimetabolites
Mucositis (Main DLT)
BMS, N/V
Dose Limiting Toxicity
Folate Antagonists
BMS and mucositis (DLT)
hepatotoxicity, interstitial pneumonitis
Dose Limiting Toxicity
Purine Antagonists
BMS, renal tubule damage (DLT)
Dose Limiting Toxicity
Pyrimidine Antagonists and Cytidine Analogues
BMS (DLT)
mucositis, diarrhea
Dose Limiting Toxicity
Topoisomerase I inhibitors
BMS (Main DLT)
diarrhea (DLT for irinotecan)
Dose Limiting Toxicity
Topoisomerase II - Anthracyclines
BMS and cardiac toxicity
Dose Limiting Toxicity
Topoisomerase II - Epipodophyllotoxins
BMS (DLT)
Dose Limiting Toxicity
Taxanes
BMS (DLT) cumulative neurotoxicity (paclitaxel)
Dose Limiting Toxicity
LHRH agonists
increase bone paine, tumor flair, hot flashes
Dose Limiting Toxicity
estrogen receptor modulators
menopausal symp., N/V, vag bleed, THROMBOTIC EVENTS
Dose Limiting Toxicity
aromatase inhibitors
N/V, hot flashes, tumor flair, wt gain
Dose Limiting Toxicity
antiandrogens
Diarrhea, gynecomastia, sex dysfunction, hematuria
Dose Limiting Toxicity
Corticosteroids
Hyperglycemia
Dose Limiting Toxicity
Signal transductase inhibitors
N/V/D, skin rash, dry skin
Dose Limiting Toxicity
Monoclonal antibodies
hypersensitivity reactions
Dose Limiting Toxicity
Interferons
Flu-like syndrome, progressive fatigue (DLT)
BMS
Dose Limiting Toxicity
Interleukins
CV, GI, wt gain, neuologic, renal toxicities, rash
Ifosfamide
Hemorrhagic cystitis
Cyclofosphamide
Hemorrhagic cystitis, pulmonary fibrosis
cardiac toxicity, BMS
Busulfan
pulmonary fibrosis
Cisplatin
Nephrotoxicity, some oto and neuro
Carboplatin
BMS, neuropthaties
Oxaliplatin
peripheral neuropathy, BMS
Dacarbazine
lots of anticipatory N/V
Cytarabine
cerebeller ataxia, conjunctivitis, hand-foot synd
5-FU
ataxia, dermatologic toxicities, ophthalmic changes
irinotecan and topotecan
fever/flu-like symp., elevated LFTs
Anthrcyclines
vesicant, red urine, hand-foot syndrome
Etoposide
HOTN (cremaphor vehicle), phlebitis, hypersensitivity
Vincristine
Constipation, bowel paralysis
Vinblastine
BMS
Taxanes
Hypersensitivities, ?
Ixabepilone
neutropenia, fatigue, hand-foot syndrome, diarrhea, neuropathy
Bleomycin
pulmonary fibrosis @ >100-450U
Hydroxyurea
Hypersensitivity
Imatinib
edema, skin rash, N/V/D
Gefitinib
N/V/D, rash, acne, dry skin
Cetuximab
severe infusion reactions, uricaria, HoTN, rash
Bevacizumab
HTN, tiredness, diarrhea, impaired healing
Thalidomide
neuropathy, constipation, rash, increase risk of DVT
tretinoin
dry skin, HA, fever, ocular, liver, and lipase changes
arsenic trioxide
QT interval prolongation, fever, rash, edema, wt gain