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15 Cards in this Set
- Front
- Back
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5 cardinal signs of inflammation |
Redness Pain or pruritus Loss of function Heat Swelling |
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What is redness and heat caused by? |
Vasodilation Increased blood flow |
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Inflammatory factors that cause vasodilation |
Histamine Nitric oxide Serotonin Platelet activating factor Bradykinin Prostaglandins |
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What is swelling caused by |
Increased vascular permeability Influx of inflammatory cells |
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Mediators of pruritus |
Histamine Substance P Proteolytic enzymes Prostaglandin E IL 31 |
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Mediators of inflammation |
Histamine Platelet activating factor Serotonin complement proteins Nitric oxide Bradykinin Prostaglandins Leukotrienes cytokines/chemokines |
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How does histamine cause vasodilation |
Attaches to cell Causes a G protein cascade Releases Nitric Oxide Causes relaxation of smooth muscle so blood can flow through |
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How does serotonin cause vasodilation |
Same as histamine Stimulates g-proteins to release NO relaxation of smooth muscle |
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How does platelet activating factor cause vasodilation? |
binds to PAF receptor on muscle cell causes g proteins and tyrosine kinases to form a signal transduction Causes vasodilation, secretion and degranulation |
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What does bradykinin cause? |
Vasodilation Pain Activation of prostaglandins/leukotrienes |
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Acute phase proteins |
complement proteins Iron binding proteins clotting factors Protease inhibitors C- reactive protein Serum amyloid A |
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What is c-reactive protein |
soluble pattern recognition receptor Recognises phosphocholine from cell membranes and microorganisms Other side can bind to fc receptors on neutrophils
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What is serum amyloid A |
Can activate toll-like receptors Chemoattractant for inflammatory cells |
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What do protease inhibitors do? |
Stop proteases that are released by dying cells |
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meow |
meow |
