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132 Cards in this Set
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Abilify
|
Aripiprazole
|
Schizophenis, bipolar
10-15 mg qday N/V, somnolence, TD, tremor, hyperglycemia. 3A4 and 2D6 interactions |
|
Actos
|
pioglitizone
|
DM- selectively stimulates the nuclear receptor peroxisome proliferator-activated receptor gamma (PPAR-γ) and to a lesser extent PPAR-α.[2][3] It modulates the transcription of the insulin-sensitive genes involved in the control of glucose and lipid metabolism in the muscle, adipose tissue, and the liver. As a result, pioglitazone reduces insulin resistance in the liver and peripheral tissues; increases the expense of insulin-dependent glucose; decreases withdrawal of glucose from the liver; reduces quantity of glucose, insulin and glycated hemoglobin in the bloodstream.
15 or 30 mg daily peripheral edema, Liver, CHF |
|
Remicade
|
infliximab
|
Given IV: Crohn's 5mg/kg; RA 3mg/kg week 0,2,6
Infliximab neutralizes the biological activity of TNFα by binding with high affinity to the soluble (free floating in the blood) and transmembrane (located on the outer membranes of T cells and similar immune cells) forms of TNFα and inhibits or prevents the effective binding of TNFα with its receptors. Biological activities that are attributed to TNFα include: induction of proinflammatory cytokines such as interleukin (IL) 1 and IL 6, enhancement of leukocyte movement or migration from the blood vessels into the tissues by increasing the permeability of endothelial layer of blood vessels; and increasing the release of adhesion molecules. SE: TB, cancers, infections |
|
Humera
|
adalimumab
|
human derived TNF alpha inhibitor
Given SC: RA 40 mg q2weeks, Crohn's 160mg, then 80 mg at 2 week intervals, then 40mg q2weeks. Psoriasis 80mg, then 40 q2weeks starting 1 week later. Peds arthritis: 30mg q2weeks for 15 to less than 30kg; 40 q2weeks 30 kg and up Lymphoma, melanoma, other cancers, severe infections, lupus-like syndrome, CHF exacerbation are associated with these drugs. Should not be given with rituxin, anakinra or abatacept |
|
Enbrel
|
etanercept
|
RA, AS severe plaque arthritis
TNF inhibitor 50 mg SC qweek |
|
Cymbalta
|
duloxetine
|
Depression/anxiety/neuropathy/pain/stress incont.
SNRI 40-60 mg divided qd-bid DI/CI:thoridazine, MAOIs, uncontrolled narrow angle glaucoma, other similar medications CrCl < 30ml/min |
|
Zyprexa
|
olanzapine
|
Schizophrenia, bipolar
atypical anti-psychotic. 2.5-20 mg/day PO, ODT, IM orthostatic hypotension |
|
Lexapro
|
escitalopram
|
|
|
Rituxan
|
rituximab
|
a chimeric monoclonal antibody against the protein CD20, which is primarily found on the surface of B cells. Rituximab is used in the treatment of many lymphomas, leukemias, transplant rejection and some autoimmune disorders.
375mg/m2 APAP+ diphenhydramine prior; slow infusion; monitor for INF reaction; often 30-120 min into 1st dose |
|
Copaxone
|
Glatiramer Acetate
|
For MS
20mg SC daily |
|
Altace
|
ramipril
|
2.5-20mg divided qday to bid
CHF: Start 1.25-2.5 mg once daily. Target dose: 10 mg once daily; decrease diuretic dose CrCl <40 mL/minute: Administer 25% of normal dose |
|
Amaryl
|
glimipiride
|
1-4 mg daily
Dosing adjustment/comments in renal impairment: Clcr<22 mL/minute: Initial starting dose should be 1 mg and dosage increments should be based on fasting blood glucose levels |
|
Ambien CR
|
zolpidem
|
12.5 mg HS
a short-acting nonbenzodiazepine hypnotic that potentiates gamma-aminobutyric acid (GABA), an inhibitory neurotransmitter, by binding to GABAA receptors at the same location as benzodiazepines.15 min onset and short half-life (2–3 hours). |
|
Aricept
|
donepazil
|
Alzheimers/dementia
5-10 mg daily reversible acetylcholinesterase inhibitor |
|
Arimidex
|
anastrazole
|
aromatase inhibitor
adjuvant for ER+ Breast CA 1mg daily osteoporosis/fx |
|
Arthrotec
|
diclofenac/misoprostol
|
50/200mg- up to 4x daily
75/200mg BID |
|
Voltaren
Cataflam |
diclofenac
|
Analgesia/primary dysmenorrhea: Starting dose: 50 mg orally 3 times daily. Maximum dose: 150 mg/day.
Rheumatoid arthritis: 150-200 mg/day orally in 2-4 divided doses (100 mg/day of sustained release product). Osteoarthritis: 100-150 mg/day orally in 2-3 divided doses (100-200 mg/day of sustained release product). Supplied: (Cataflam® - fastest onset of action) 50 mg tablet (K+ salt). (Voltaren®) Delayed release (enteric coated tab - Na+ salt): 25 mg, 50 mg, 75 mg. (Voltaren®-XR) Extended release tab: 100 mg Maximum Daily Dose: 225 mg; XR: 200 mg |
|
Asacol
|
mesalamine, 5-ASA
|
For the treatment of mildly to moderately active ulcerative colitis
2.4 grams (2X 400 mg TID) X 6 weeks. maintenance: 1.6 grams daily, in divided doses. **Two Asacol (mesalamine delayed-release tablets) 400 mg tablets have not been shown to be bioequivalent to one Asacol® HD (mesalamine) delayed-release 800 mg tablet. |
|
Astelin
|
azelastine NS
|
Allergies; Competes with histamine for H1-receptor sites on effector cells and inhibits the release of histamine and other mediators involved in the allergic response. When used intranasally, reduces hyper-reactivity of the airways; increases the motility of bronchial epithelial cilia, improving mucociliary transport
1-2 sprays per nostril BID |
|
Atacand
|
candesartan
|
8-32mg divided qday to BID
CHF- 4mg with target of 32 mg |
|
Atarax
Vistaril |
Hydroxyzine
|
antihistamine; 50 mg QID
sedation, anticholinergic |
|
Avalide
|
irbesartan/HCTZ
|
150mg/12.5 mg daily
|
|
Avandia
|
rosiglitazone
|
4-8mg divided qday to BID
|
|
Avapro
|
irbesartan
|
ARB- Preg cat X for ARB and ACEI
150-300 mg daily |
|
Avelox
|
moxifloxacin
|
400 mg Qday
CI: DM, preg X, QT prolongation, epilepsy, children |
|
Avodart
|
Dutasteride
|
BPH; 5-alpha reductase inhibitor (inh conversion of test to DHT)
0.5 mg daily Pregnacy X- do not handle drug. |
|
Benicar
|
olmesartan
|
ARB- 20-40 mg Qday
|
|
Boniva
|
ibandronate
|
bisphosphonate
150mg qmonth |
|
Byetta
|
exenatide inj
|
GLP-1 receptor agonist that enhances glucose-dependent insulin secretion by the pancreatic beta-cell, suppresses inappropriately elevated glucagon secretion, and slows gastric emptying.
** Type II only Initial: 5 mcg SQ bid within 60 min prior to a meal (morning and evening). After 1 month, may be increased to 10 mcg SQ twice daily (based on response). Renal Not recommended in patients CRCL < 30 ml/min. |
|
Caduet
|
Amlodipine/atorvastatin
|
5/10 mg daily
|
|
Calan
|
Verapamil
|
80 mg TID
|
|
Carafate
|
sucralfate
|
1000mg QID AC+HS
|
|
Cardura
|
doxazosin
|
1-10mg daily
|
|
Cardizem, Cartia
|
Diltiazem
|
120-240 mg daily depending on indication
|
|
Catapres
|
Clonidine
|
0.1-0.6 BID
|
|
CellCept
|
mycophenolate mofetil
|
1000mg BID
|
|
Chantix
|
varenicline
|
nicotine receptor partial agonist;
Days 1 – 3: 0.5 mg once daily Days 4 – 7: 0.5 mg twice daily Day 8 through End of treatment: 1 mg twice daily not for pts with hx mental illness; causes depression, ect. CRCL <30 mL/minute: Initiate: 0.5 mg once daily; maximum dose: 0.5 mg twice daily. Hemodialysis: Maximum dose: 0.5 mg once daily. |
|
Cialis
|
tadalafil
|
PDE5 inhibitor
10 mg prior of 2.5 mg daily Nitrates- wait 48hrs hearing and vision loss |
|
Ciprodex Otic
|
cipro 0.3%, dexamethasone 0.1% ear gtt
|
4 gtt BID x 7 days
|
|
Clarinex
|
desloratadine
|
5 mg once daily
|
|
Cleocin
|
clindamycin
|
lincosamide abx
150-300 mg Q6H |
|
Clozaril
|
clozapine
|
Schizo/bipolar
1DOSING: ADULTS - Schizophrenia: Initial: 12.5 mg once or twice daily; increased, as tolerated, in increments of 25-50 mg/day to a target dose of 300-450 mg/day after 2-4 weeks, may require doses as high as 600-900 mg/day |
|
Clozaril dose adjustments
|
Termination of therapy: If dosing is interrupted for >/=48 hours, therapy must be reinitiated at 12.5-25 mg/day; may be increased more rapidly than with initial titration, unless cardiopulmonary arrest occurred during initial titration.
In the event of planned termination of clozapine, gradual reduction in dose over a 1- to 2-week period is recommended. If conditions warrant abrupt discontinuation (leukopenia), monitor patient for psychosis and cholinergic rebound (headache, nausea, vomiting, diarrhea). |
Dosage adjustment for toxicity:
Moderate leukopenia or granulocytopenia (WBC <3000/mm3 and ANC <1500/mm3): Discontinue therapy; may rechallenge patient when WBC >3500/mm3 and/or ANC >2000/mm3. Note: Patient is at greater risk for developing agranulocytosis. Severe leukopenia or granulocytopenia (WBC <2000/mm3 and/or ANC <1000/mm3): Discontinue therapy and do not rechallenge patient. |
|
Cogentin
|
benzetropine
|
anticholenergic; Parkinson's, extrapyramidal sx, dystonia
1-4 mg qday-bid |
|
Compro
|
prochlorperazine
|
5-10 mg tid-qid
antipsychotic- MAOI interaction |
|
Concerta
|
methyphenidate
|
5-10mg BID
|
|
Cosopt
|
dorazolamide/timolol opth
|
carbonic anhydrase inhibitor/bb
1 gtt bid |
|
Cozaar
|
losartan
|
25-100 mg divided Qday to BID
|
|
Crestor
|
rosuvastatin
|
5-40 mg
Hydrophilic, 2C9 Oral: Cyclosporine: Rosuvastatin dose should not exceed 5 mg/day. Gemfibrozil: Rosuvastatin dose should not exceed 10 mg/day. Dosage adjustment for persistent, unexplained proteinuria while on 40 mg/day: Reduce dose and evaluate causes. |
|
Jantoven
|
warfarin
|
inhibits vit K dependant factors II, VII, IX, X protein C and Protein S
S isomer: 2C9 |
|
Depo Provera, provera
|
medroxyprogesterone
|
IM injection or tablet contraceptive
|
|
Desyrel
|
trazodone
|
25-200 mg HS for sleep. Up to 600mg daily for depression
|
|
Detrol
|
tolterodine
|
2mg BID or 4mg qday ER
(Crcl 10-30)/ hepatic impairment: Use with caution. 1 mg twice daily (regular release) or 2 mg daily (extended release). |
|
Diovan
|
valsartan
|
Hypertension: Initial: 80 mg or 160 mg once daily (in patients who are not volume depleted). Dose may be increased to achieve desired effect ... maximum recommended dose: 320 mg per day.
CHF: Initial: 40 mg twice daily. Titrate dose to 80 to 160 mg twice daily, as tolerated. Maximum daily dose: 320 mg. Left ventricular dysfunction after MI: Initial: 20 mg twice daily. Titrate dose to target of 160 mg twice daily as tolerated. |
|
Ditropan
|
oxybutynin
|
5-10mg qday
anticholinergic SE |
|
Doxycycline
|
Doxylin
Perostat Vibramycin |
100-200mg daily PO or IV divided Qday to BID
|
|
Dyazide
|
HCTZ/triamterene
|
25/37.5mg daily
50/75 mg daily traimterene is K sparing |
|
Effexor
|
venlafaxine
|
75-375mg divided BID-TID
ER: 37.5-225mg daily Clcr 10-70 mL/minute: Decrease dose by 25%; decrease total daily dose by 50% if dialysis patients; dialysis patients should receive dosing after dialysis Reduce 50% for liver impairment. Taper over 2 weeks if taking for more than 6wks. |
|
amitriptyline
|
Elavil
Endep |
TCA
50-100 mg divided anticholinergic SE orth hypotension |
|
Evista
|
raloxofene
|
selective estrogent receptor modulator (SERM) estrogenic on bone, antiestrigenic breast and unterus
60mg qday |
|
fluticasone
|
Flonase
Flovent |
2 sp each nostril 1-2x daily
MDI- 1-2 puff BID |
|
Focalin
|
dexymethylphenidate
|
5 mg BID
|
|
Forteo
|
teriparatide
|
recombinant parathyroid hormone
20 mcg SC daily for osteoporosis Once-daily administration of teriparatide stimulates new bone formation on trabecular and cortical (periosteal and/or endosteal) bone surfaces by preferential stimulation of osteoblastic activity over osteoclastic activity. |
|
Geodon
|
ziprazidone
|
20-100 mg BID; over 80 mg BID may not add benefit.
Acute agitation (schizophrenia): 10 mg IM every 2 hours or 20 mg every 4 hours (maximum: 40 mg/day). QT prolongation CI with Qt prolonging drugs. NMS, TD |
|
Gleevec
|
imatinib
|
Tx of CML, ALL, GIST, other cancers
a specific inhibitor of a number of tyrosine kinase enzymes. In chronic myelogenous leukemia, the Philadelphia chromosome leads to a fusion protein of abl with bcr (breakpoint cluster region), termed bcr-abl.Imatinib works by binding close to the ATP binding site of bcr-abl, locking it in a closed or self-inhibited conformation, and therefore inhibiting the enzyme activity of the protein semi-competitively 400-600mg for ALL,CLL 400mg-800mg daily for GIST; adjust for myelosuppression |
|
Glucatrol
|
glipizide
|
2.5-20mg XL
2.5-40mg reg release divided BID |
|
Humalog
|
lispro
|
onset 10-15 min
|
|
Microzide
|
HCTZ
|
25-
|
|
Hytrin
|
terazosin
|
1-10 mg daily
|
|
Hyzaar
|
losartan/HCTZ
|
100/12.5mg
|
|
Inverase
|
saquinavir
|
PI
1000mg BID with ritonavir |
|
Imitrex
|
sumatriptan
|
Oral: 50-100mg; max 200 mg daily; If a satisfactory response has not been obtained at 2 hours, a second dose may be administered.
Nasal: 5-20mg NTE 40mg/24hrs SC: 6mg; may repeat in 1 hr NTE 6mg./24hrs cardiac SEs |
|
Januvia
|
sitagliptin
|
inhibits dipeptidyl peptidase-4 (DPP-4) enzyme, slowing the inactivation of incretin hormones.When blood glucose concentrations are normal or elevated, GLP-1 and GIP increase insulin synthesis and release from pancreatic beta cells by intracellular signaling pathways involving cyclic AMP. GLP-1 also lowers glucagon secretion from pancreatic alpha cells, leading to reduced hepatic glucose production. By increasing and prolonging active incretin levels, JANUVIA increases insulin release and decreases glucagon levels in the circulation in a glucose-dependent manner.
Dose 100mg daily with or without food. CrCl 30-50ml/min: 50 mg daily less than 30 ml/min or HD: 25 mg daily |
|
Lamactal
|
lamotrigine
|
Partial sz; bipolar do
titrate by 25-50mg/week to 100-200 mg daily in divided doses (up to 400mg/daily) Rash- like SJS or TEN with VPA requires higher doses; titrate by 50-100mg/week to 300-500mg/day in divided doses |
|
Laniazide
|
isoniazid
|
Adults: 5mg/kg/day PO (maximum 300mg);or 15mg/kg (maximum 900mg) 2-3 times weekly.
|
|
TB regimen
|
Ethambutol Dosing: 15-25 mg/kg up to 2500 mg orally once daily.
Isoniazid Adults: 5mg/kg/day PO (maximum 300mg);or 15mg/kg (maximum 900mg) 2-3 times weekly. Pyrazinamide Adults: 15 to 30 mg/kg/day (maximum of 2 grams daily). Alternative regimen: 50 to 70 mg/kg two or three times weekly (maximum 3 grams/dose). rifabutin (Mycobutin): 300 mg orally once daily or 150 mg orally twice a day given with a meal. |
TB: 10-20 mg/kg up to 600 mg oral or IV once daily.
Synergy gram (+): (900-1200 mg/day in 3 divided doses): Usual dose: 300 mg orally every 8 hours. Some recommend 600 mg orally once daily. |
|
Levemir
|
insulin detemir
|
long acting insulin; long acting by virtue of albumin binding
|
|
Levitra
|
vardenafil
|
5-10 mg daily
3A4 inhibitors- max of 2.5 to 5mg daily |
|
Lexapro
|
escitalopram
|
10-20 mg daily
|
|
Lotensin
|
benazepril
|
20-40 mg daily
|
|
Lotrel
|
amlodipine/benazapril
|
5/20 mg
|
|
Lotramin
Mycelex |
clotrimazole
|
qday
|
|
Lovaza
|
Omega-3 FA
|
4 grams divided 1-2x day
|
|
Lumigan
|
bimatoprost
|
prostaglandin to decrease intra occular pressure
Dosed 1 gtt qday |
|
Lunesta
|
eszopicione
|
2-3 mg HS
with 3A4 inh: 1-2 mg sig. liver dz: max of 2mg |
|
Lyrica
|
pregabalin
|
epilepy, neuropathic pain
50-100 mg TID Crcl 15 to 30 ml/min: 25 to 150 mg/day given once daily or in 2 divided doses. Crcl < 15: 25 to 75 mg once daily. ike gabapentin, pregabalin binds to the alpha2delta subunit of the voltage-dependent calcium channel in the CNS, decreases the release of glutamate, norepi, and substance P, increases neuronal GABA levels by producing a dose-dependent increase in glutamic acid decarboxylase activity.[2] Glutamic acid decarboxylase (GAD) is the enzyme that converts the excitatory neurotransmitter glutamate into GABA in a single step. potentiates benzodiazepines, barbiturates & other depressants. |
|
Micardis
|
telmisartan
|
20-80mg daily
|
|
Mirapex
|
pramipexole
|
dopamine agonist
May be taken with food to decrease nausea. Initial: 0.375 mg/day given in 3 divided doses, increase gradually by 0.125 mg/dose every 5-7 days; range: 1.5-4.5 mg/day Clcr 35-59 mL/minute: Initial: 0.125 mg twice daily (maximum dose: 1.5 mg twice daily) Clcr 15-34 mL/minute: Initial: 0.125 mg once daily (maximum dose: 1.5 mg once daily) Clcr<15 mL/minute (or hemodialysis patients): Not adequately studied |
|
Namenda
|
memantidine
|
(NMDA) receptor antagonist
start at 5mg daily; titrate to 10mg bid |
|
Nasocort AQ
|
triamcinolone NS
|
2 sprays each nostril qday
|
|
Nasonex
|
mometisone NS
|
2 sprays each nostril qday
|
|
ketoconazole
|
Nizoral
Extina |
potent 3A4 inhibitor.
|
|
Nolvadex
|
tamoxifen
|
estrogen receptor antagonist
20-40 mg daily to BID |
|
Norvasc
|
amlodipine
|
5-20mg daily
|
|
Novolog
|
insulin Aspart
|
5-10 min before a meal
|
|
Omnicef
|
cefdinir
|
3rd gen ceph
300 mg PO Q12H 600 mg PO qday |
|
Paxil
|
paroxetine
|
20 mg daily
|
|
Prograf
|
tacrolimus FK506
|
Divide BID
target FK levels 5-20 depending on indication |
|
Prometrium
Endometrin |
progesterone
|
200mg daily
|
|
Proscar
Propecia |
finasteride
|
5-alpha-reductase inhibitor testosterone to DHT
5mg daily |
|
Provigil
|
modafinil
|
200mg Qdaily for narcolepsy
Skin rash- SJS, TEN CI: contraceptives |
|
Pulmicort
|
budesonide inh
|
200mcg BID
|
|
Requip
|
ropinirole
|
dopamine agonist
1 mg TID |
|
Restasis
|
cyclosporin opthalmic
|
1 gtt q12h
|
|
Revatio
|
sildenafil
|
For pulm htn- PDE5 inhibitor
20 mg TID |
|
Rifadin
Rimactane |
rifampin
|
10mg/kg daily
|
|
Rozerem
|
ramelteon
|
melatonin agonist
8mg taken 30 min before bed |
|
Sensispar
|
cinecalcet
|
secondary hyper PTH with CKD on dialysis and hypercalcemia in PTH CA
30-180 mg qday, BID |
|
Seroquel
|
quetiapine
|
300 mg divided daily, BID, TID
|
|
Skelaxin
|
metaxalone
|
muscle relaxant
800mg TID to QID |
|
Soma
|
carisoprodol
|
250mg QID
|
|
Strattera
|
atomoxetine
|
ADHD NE reuptake inhibitor
80 mg/daily or BID |
|
Suboxone
|
buprenorphine and naloxone
|
partial opiate partial agonist and competitive antagonist,
12 mg Qday |
|
Symbicort
|
budesonide, formoterol
|
BID
|
|
Tamiflu
|
Osteltamivir
|
75 mg BID for 5 days
|
|
Tetracyn
Sumycin |
tetracycline
|
500 mg BID
|
|
Tobradex
|
tobramycin, dexamethasone, opthalmic
|
1-2 drops q4-6
|
|
TriCor
|
fenofibrate
|
145 mg daily
|
|
Trleptal
|
oxcarbazepine
|
600mg BID
|
|
Ventolin, Proventil, ProAir
|
albuterol
|
|
|
Vigamox
|
moxifloxacin ocular
|
1 gtt TID
|
|
Vivelle-DOT
|
transdermal estradiol
|
2x weekly on addomen
|
|
Vytorin
|
ezetimbe simvastin
|
10/20mg
|
|
Xalatan
|
latanoprost
|
Prostaglandin
1 gtt qday |
|
Xopenex
|
levalbuterol
|
|
|
Zestril
|
lisinopril
|
|
|
Yaz
|
drospirenone and ethinyl estradiol
|
|
|
Zoloft
|
sertraline
|
|
|
Zyloprim
|
Allopurinol
|
|
|
Zyprexa
|
olnazapine
|
|
|
Aviane
|
ethinyl estradiol, desogestrel
ethinyl estradiol, levonorgestrel |
|
|
Ortho tri cyclin
|
norgestimate/EE
|
|