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132 Cards in this Set

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Abilify
Aripiprazole
Schizophenis, bipolar
10-15 mg qday
N/V, somnolence, TD, tremor, hyperglycemia.
3A4 and 2D6 interactions
Actos
pioglitizone
DM- selectively stimulates the nuclear receptor peroxisome proliferator-activated receptor gamma (PPAR-γ) and to a lesser extent PPAR-α.[2][3] It modulates the transcription of the insulin-sensitive genes involved in the control of glucose and lipid metabolism in the muscle, adipose tissue, and the liver. As a result, pioglitazone reduces insulin resistance in the liver and peripheral tissues; increases the expense of insulin-dependent glucose; decreases withdrawal of glucose from the liver; reduces quantity of glucose, insulin and glycated hemoglobin in the bloodstream.
15 or 30 mg daily
peripheral edema, Liver, CHF
Remicade
infliximab
Given IV: Crohn's 5mg/kg; RA 3mg/kg week 0,2,6
Infliximab neutralizes the biological activity of TNFα by binding with high affinity to the soluble (free floating in the blood) and transmembrane (located on the outer membranes of T cells and similar immune cells) forms of TNFα and inhibits or prevents the effective binding of TNFα with its receptors. Biological activities that are attributed to TNFα include: induction of proinflammatory cytokines such as interleukin (IL) 1 and IL 6, enhancement of leukocyte movement or migration from the blood vessels into the tissues by increasing the permeability of endothelial layer of blood vessels; and increasing the release of adhesion molecules.
SE: TB, cancers, infections
Humera
adalimumab
human derived TNF alpha inhibitor
Given SC: RA 40 mg q2weeks, Crohn's 160mg, then 80 mg at 2 week intervals, then 40mg q2weeks. Psoriasis 80mg, then 40 q2weeks starting 1 week later. Peds arthritis: 30mg q2weeks for 15 to less than 30kg; 40 q2weeks 30 kg and up
Lymphoma, melanoma, other cancers, severe infections, lupus-like syndrome, CHF exacerbation are associated with these drugs. Should not be given with rituxin, anakinra or abatacept
Enbrel
etanercept
RA, AS severe plaque arthritis
TNF inhibitor
50 mg SC qweek
Cymbalta
duloxetine
Depression/anxiety/neuropathy/pain/stress incont.
SNRI
40-60 mg divided qd-bid
DI/CI:thoridazine, MAOIs, uncontrolled narrow angle glaucoma, other similar medications
CrCl < 30ml/min
Zyprexa
olanzapine
Schizophrenia, bipolar
atypical anti-psychotic.
2.5-20 mg/day PO, ODT, IM
orthostatic hypotension
Lexapro
escitalopram
Rituxan
rituximab
a chimeric monoclonal antibody against the protein CD20, which is primarily found on the surface of B cells. Rituximab is used in the treatment of many lymphomas, leukemias, transplant rejection and some autoimmune disorders.
375mg/m2
APAP+ diphenhydramine prior; slow infusion; monitor for INF reaction; often 30-120 min into 1st dose
Copaxone
Glatiramer Acetate
For MS
20mg SC daily
Altace
ramipril
2.5-20mg divided qday to bid
CHF: Start 1.25-2.5 mg once daily. Target dose: 10 mg once daily; decrease diuretic dose
CrCl <40 mL/minute: Administer 25% of normal dose
Amaryl
glimipiride
1-4 mg daily
Dosing adjustment/comments in renal impairment: Clcr<22 mL/minute: Initial starting dose should be 1 mg and dosage increments should be based on fasting blood glucose levels
Ambien CR
zolpidem
12.5 mg HS
a short-acting nonbenzodiazepine hypnotic that potentiates gamma-aminobutyric acid (GABA), an inhibitory neurotransmitter, by binding to GABAA receptors at the same location as benzodiazepines.15 min onset and short half-life (2–3 hours).
Aricept
donepazil
Alzheimers/dementia
5-10 mg daily
reversible acetylcholinesterase inhibitor
Arimidex
anastrazole
aromatase inhibitor
adjuvant for ER+ Breast CA
1mg daily
osteoporosis/fx
Arthrotec
diclofenac/misoprostol
50/200mg- up to 4x daily
75/200mg BID
Voltaren
Cataflam
diclofenac
Analgesia/primary dysmenorrhea: Starting dose: 50 mg orally 3 times daily. Maximum dose: 150 mg/day.
Rheumatoid arthritis: 150-200 mg/day orally in 2-4 divided doses (100 mg/day of sustained release product).
Osteoarthritis: 100-150 mg/day orally in 2-3 divided doses (100-200 mg/day of sustained release product).

Supplied:
(Cataflam® - fastest onset of action) 50 mg tablet (K+ salt). (Voltaren®) Delayed release (enteric coated tab - Na+ salt): 25 mg, 50 mg, 75 mg. (Voltaren®-XR) Extended release tab: 100 mg

Maximum Daily Dose: 225 mg; XR: 200 mg
Asacol
mesalamine, 5-ASA
For the treatment of mildly to moderately active ulcerative colitis
2.4 grams (2X 400 mg TID) X 6 weeks.
maintenance:
1.6 grams daily, in divided doses.
**Two Asacol (mesalamine delayed-release tablets) 400 mg tablets have not been shown to be bioequivalent to one Asacol® HD (mesalamine) delayed-release 800 mg tablet.
Astelin
azelastine NS
Allergies; Competes with histamine for H1-receptor sites on effector cells and inhibits the release of histamine and other mediators involved in the allergic response. When used intranasally, reduces hyper-reactivity of the airways; increases the motility of bronchial epithelial cilia, improving mucociliary transport
1-2 sprays per nostril BID
Atacand
candesartan
8-32mg divided qday to BID
CHF- 4mg with target of 32 mg
Atarax
Vistaril
Hydroxyzine
antihistamine; 50 mg QID
sedation, anticholinergic
Avalide
irbesartan/HCTZ
150mg/12.5 mg daily
Avandia
rosiglitazone
4-8mg divided qday to BID
Avapro
irbesartan
ARB- Preg cat X for ARB and ACEI
150-300 mg daily
Avelox
moxifloxacin
400 mg Qday
CI: DM, preg X, QT prolongation, epilepsy, children
Avodart
Dutasteride
BPH; 5-alpha reductase inhibitor (inh conversion of test to DHT)
0.5 mg daily
Pregnacy X- do not handle drug.
Benicar
olmesartan
ARB- 20-40 mg Qday
Boniva
ibandronate
bisphosphonate
150mg qmonth
Byetta
exenatide inj
GLP-1 receptor agonist that enhances glucose-dependent insulin secretion by the pancreatic beta-cell, suppresses inappropriately elevated glucagon secretion, and slows gastric emptying.
** Type II only
Initial: 5 mcg SQ bid within 60 min prior to a meal (morning and evening). After 1 month, may be increased to 10 mcg SQ twice daily (based on response).
Renal
Not recommended in patients CRCL < 30 ml/min.
Caduet
Amlodipine/atorvastatin
5/10 mg daily
Calan
Verapamil
80 mg TID
Carafate
sucralfate
1000mg QID AC+HS
Cardura
doxazosin
1-10mg daily
Cardizem, Cartia
Diltiazem
120-240 mg daily depending on indication
Catapres
Clonidine
0.1-0.6 BID
CellCept
mycophenolate mofetil
1000mg BID
Chantix
varenicline
nicotine receptor partial agonist;
Days 1 – 3: 0.5 mg once daily
Days 4 – 7: 0.5 mg twice daily
Day 8 through End of treatment: 1 mg twice daily
not for pts with hx mental illness; causes depression, ect.
CRCL <30 mL/minute: Initiate: 0.5 mg once daily; maximum dose: 0.5 mg twice daily.

Hemodialysis: Maximum dose: 0.5 mg once daily.
Cialis
tadalafil
PDE5 inhibitor
10 mg prior of 2.5 mg daily
Nitrates- wait 48hrs
hearing and vision loss
Ciprodex Otic
cipro 0.3%, dexamethasone 0.1% ear gtt
4 gtt BID x 7 days
Clarinex
desloratadine
5 mg once daily
Cleocin
clindamycin
lincosamide abx
150-300 mg Q6H
Clozaril
clozapine
Schizo/bipolar
1DOSING: ADULTS - Schizophrenia: Initial: 12.5 mg once or twice daily; increased, as tolerated, in increments of 25-50 mg/day to a target dose of 300-450 mg/day after 2-4 weeks, may require doses as high as 600-900 mg/day
Clozaril dose adjustments
Termination of therapy: If dosing is interrupted for >/=48 hours, therapy must be reinitiated at 12.5-25 mg/day; may be increased more rapidly than with initial titration, unless cardiopulmonary arrest occurred during initial titration.
In the event of planned termination of clozapine, gradual reduction in dose over a 1- to 2-week period is recommended. If conditions warrant abrupt discontinuation (leukopenia), monitor patient for psychosis and cholinergic rebound (headache, nausea, vomiting, diarrhea).
Dosage adjustment for toxicity:
Moderate leukopenia or granulocytopenia (WBC <3000/mm3 and ANC <1500/mm3): Discontinue therapy; may rechallenge patient when WBC >3500/mm3 and/or ANC >2000/mm3. Note: Patient is at greater risk for developing agranulocytosis.
Severe leukopenia or granulocytopenia (WBC <2000/mm3 and/or ANC <1000/mm3): Discontinue therapy and do not rechallenge patient.
Cogentin
benzetropine
anticholenergic; Parkinson's, extrapyramidal sx, dystonia
1-4 mg qday-bid
Compro
prochlorperazine
5-10 mg tid-qid
antipsychotic- MAOI interaction
Concerta
methyphenidate
5-10mg BID
Cosopt
dorazolamide/timolol opth
carbonic anhydrase inhibitor/bb
1 gtt bid
Cozaar
losartan
25-100 mg divided Qday to BID
Crestor
rosuvastatin
5-40 mg
Hydrophilic, 2C9
Oral: Cyclosporine: Rosuvastatin dose should not exceed 5 mg/day. Gemfibrozil: Rosuvastatin dose should not exceed 10 mg/day. Dosage adjustment for persistent, unexplained proteinuria while on 40 mg/day: Reduce dose and evaluate causes.
Jantoven
warfarin
inhibits vit K dependant factors II, VII, IX, X protein C and Protein S
S isomer: 2C9
Depo Provera, provera
medroxyprogesterone
IM injection or tablet contraceptive
Desyrel
trazodone
25-200 mg HS for sleep. Up to 600mg daily for depression
Detrol
tolterodine
2mg BID or 4mg qday ER
(Crcl 10-30)/ hepatic impairment: Use with caution. 1 mg twice daily (regular release) or 2 mg daily (extended release).
Diovan
valsartan
Hypertension: Initial: 80 mg or 160 mg once daily (in patients who are not volume depleted). Dose may be increased to achieve desired effect ... maximum recommended dose: 320 mg per day.

CHF: Initial: 40 mg twice daily. Titrate dose to 80 to 160 mg twice daily, as tolerated. Maximum daily dose: 320 mg.
Left ventricular dysfunction after MI: Initial: 20 mg twice daily. Titrate dose to target of 160 mg twice daily as tolerated.
Ditropan
oxybutynin
5-10mg qday
anticholinergic SE
Doxycycline
Doxylin
Perostat
Vibramycin
100-200mg daily PO or IV divided Qday to BID
Dyazide
HCTZ/triamterene
25/37.5mg daily
50/75 mg daily
traimterene is K sparing
Effexor
venlafaxine
75-375mg divided BID-TID
ER: 37.5-225mg daily
Clcr 10-70 mL/minute: Decrease dose by 25%; decrease total daily dose by 50% if dialysis patients; dialysis patients should receive dosing after dialysis
Reduce 50% for liver impairment. Taper over 2 weeks if taking for more than 6wks.
amitriptyline
Elavil
Endep
TCA
50-100 mg divided
anticholinergic SE
orth hypotension
Evista
raloxofene
selective estrogent receptor modulator (SERM) estrogenic on bone, antiestrigenic breast and unterus
60mg qday
fluticasone
Flonase
Flovent
2 sp each nostril 1-2x daily
MDI- 1-2 puff BID
Focalin
dexymethylphenidate
5 mg BID
Forteo
teriparatide
recombinant parathyroid hormone
20 mcg SC daily
for osteoporosis
Once-daily administration of teriparatide stimulates new bone formation on trabecular and cortical (periosteal and/or endosteal) bone surfaces by preferential stimulation of osteoblastic activity over osteoclastic activity.
Geodon
ziprazidone
20-100 mg BID; over 80 mg BID may not add benefit.
Acute agitation (schizophrenia): 10 mg IM every 2 hours or 20 mg every 4 hours (maximum: 40 mg/day).
QT prolongation CI with Qt prolonging drugs. NMS, TD
Gleevec
imatinib
Tx of CML, ALL, GIST, other cancers
a specific inhibitor of a number of tyrosine kinase enzymes. In chronic myelogenous leukemia, the Philadelphia chromosome leads to a fusion protein of abl with bcr (breakpoint cluster region), termed bcr-abl.Imatinib works by binding close to the ATP binding site of bcr-abl, locking it in a closed or self-inhibited conformation, and therefore inhibiting the enzyme activity of the protein semi-competitively
400-600mg for ALL,CLL
400mg-800mg daily for GIST; adjust for myelosuppression
Glucatrol
glipizide
2.5-20mg XL
2.5-40mg reg release divided BID
Humalog
lispro
onset 10-15 min
Microzide
HCTZ
25-
Hytrin
terazosin
1-10 mg daily
Hyzaar
losartan/HCTZ
100/12.5mg
Inverase
saquinavir
PI
1000mg BID with ritonavir
Imitrex
sumatriptan
Oral: 50-100mg; max 200 mg daily; If a satisfactory response has not been obtained at 2 hours, a second dose may be administered.
Nasal: 5-20mg NTE 40mg/24hrs
SC: 6mg; may repeat in 1 hr NTE 6mg./24hrs
cardiac SEs
Januvia
sitagliptin
inhibits dipeptidyl peptidase-4 (DPP-4) enzyme, slowing the inactivation of incretin hormones.When blood glucose concentrations are normal or elevated, GLP-1 and GIP increase insulin synthesis and release from pancreatic beta cells by intracellular signaling pathways involving cyclic AMP. GLP-1 also lowers glucagon secretion from pancreatic alpha cells, leading to reduced hepatic glucose production. By increasing and prolonging active incretin levels, JANUVIA increases insulin release and decreases glucagon levels in the circulation in a glucose-dependent manner.
Dose 100mg daily with or without food.
CrCl 30-50ml/min: 50 mg daily
less than 30 ml/min or HD: 25 mg daily
Lamactal
lamotrigine
Partial sz; bipolar do
titrate by 25-50mg/week to 100-200 mg daily in divided doses (up to 400mg/daily)
Rash- like SJS or TEN
with VPA requires higher doses; titrate by 50-100mg/week to 300-500mg/day in divided doses
Laniazide
isoniazid
Adults: 5mg/kg/day PO (maximum 300mg);or 15mg/kg (maximum 900mg) 2-3 times weekly.
TB regimen
Ethambutol Dosing: 15-25 mg/kg up to 2500 mg orally once daily.
Isoniazid Adults: 5mg/kg/day PO (maximum 300mg);or 15mg/kg (maximum 900mg) 2-3 times weekly.
Pyrazinamide Adults: 15 to 30 mg/kg/day (maximum of 2 grams daily). Alternative regimen: 50 to 70 mg/kg two or three times weekly (maximum 3 grams/dose).
rifabutin (Mycobutin): 300 mg orally once daily or 150 mg orally twice a day given with a meal.
TB: 10-20 mg/kg up to 600 mg oral or IV once daily.
Synergy gram (+): (900-1200 mg/day in 3 divided doses): Usual dose: 300 mg orally every 8 hours. Some recommend 600 mg orally once daily.
Levemir
insulin detemir
long acting insulin; long acting by virtue of albumin binding
Levitra
vardenafil
5-10 mg daily
3A4 inhibitors- max of 2.5 to 5mg daily
Lexapro
escitalopram
10-20 mg daily
Lotensin
benazepril
20-40 mg daily
Lotrel
amlodipine/benazapril
5/20 mg
Lotramin
Mycelex
clotrimazole
qday
Lovaza
Omega-3 FA
4 grams divided 1-2x day
Lumigan
bimatoprost
prostaglandin to decrease intra occular pressure
Dosed 1 gtt qday
Lunesta
eszopicione
2-3 mg HS
with 3A4 inh: 1-2 mg
sig. liver dz: max of 2mg
Lyrica
pregabalin
epilepy, neuropathic pain
50-100 mg TID
Crcl 15 to 30 ml/min: 25 to 150 mg/day given once daily or in 2 divided doses.
Crcl < 15: 25 to 75 mg once daily.
ike gabapentin, pregabalin binds to the alpha2delta subunit of the voltage-dependent calcium channel in the CNS, decreases the release of glutamate, norepi, and substance P, increases neuronal GABA levels by producing a dose-dependent increase in glutamic acid decarboxylase activity.[2] Glutamic acid decarboxylase (GAD) is the enzyme that converts the excitatory neurotransmitter glutamate into GABA in a single step. potentiates benzodiazepines, barbiturates & other depressants.
Micardis
telmisartan
20-80mg daily
Mirapex
pramipexole
dopamine agonist
May be taken with food to decrease nausea.
Initial: 0.375 mg/day given in 3 divided doses, increase gradually by 0.125 mg/dose every 5-7 days; range: 1.5-4.5 mg/day

Clcr 35-59 mL/minute: Initial: 0.125 mg twice daily (maximum dose: 1.5 mg twice daily)
Clcr 15-34 mL/minute: Initial: 0.125 mg once daily (maximum dose: 1.5 mg once daily)
Clcr<15 mL/minute (or hemodialysis patients): Not adequately studied
Namenda
memantidine
(NMDA) receptor antagonist
start at 5mg daily; titrate to 10mg bid
Nasocort AQ
triamcinolone NS
2 sprays each nostril qday
Nasonex
mometisone NS
2 sprays each nostril qday
ketoconazole
Nizoral
Extina
potent 3A4 inhibitor.
Nolvadex
tamoxifen
estrogen receptor antagonist
20-40 mg daily to BID
Norvasc
amlodipine
5-20mg daily
Novolog
insulin Aspart
5-10 min before a meal
Omnicef
cefdinir
3rd gen ceph
300 mg PO Q12H
600 mg PO qday
Paxil
paroxetine
20 mg daily
Prograf
tacrolimus FK506
Divide BID
target FK levels 5-20 depending on indication
Prometrium
Endometrin
progesterone
200mg daily
Proscar
Propecia
finasteride
5-alpha-reductase inhibitor testosterone to DHT
5mg daily
Provigil
modafinil
200mg Qdaily for narcolepsy
Skin rash- SJS, TEN
CI: contraceptives
Pulmicort
budesonide inh
200mcg BID
Requip
ropinirole
dopamine agonist
1 mg TID
Restasis
cyclosporin opthalmic
1 gtt q12h
Revatio
sildenafil
For pulm htn- PDE5 inhibitor
20 mg TID
Rifadin
Rimactane
rifampin
10mg/kg daily
Rozerem
ramelteon
melatonin agonist
8mg taken 30 min before bed
Sensispar
cinecalcet
secondary hyper PTH with CKD on dialysis and hypercalcemia in PTH CA
30-180 mg qday, BID
Seroquel
quetiapine
300 mg divided daily, BID, TID
Skelaxin
metaxalone
muscle relaxant
800mg TID to QID
Soma
carisoprodol
250mg QID
Strattera
atomoxetine
ADHD NE reuptake inhibitor
80 mg/daily or BID
Suboxone
buprenorphine and naloxone
partial opiate partial agonist and competitive antagonist,
12 mg Qday
Symbicort
budesonide, formoterol
BID
Tamiflu
Osteltamivir
75 mg BID for 5 days
Tetracyn
Sumycin
tetracycline
500 mg BID
Tobradex
tobramycin, dexamethasone, opthalmic
1-2 drops q4-6
TriCor
fenofibrate
145 mg daily
Trleptal
oxcarbazepine
600mg BID
Ventolin, Proventil, ProAir
albuterol
Vigamox
moxifloxacin ocular
1 gtt TID
Vivelle-DOT
transdermal estradiol
2x weekly on addomen
Vytorin
ezetimbe simvastin
10/20mg
Xalatan
latanoprost
Prostaglandin
1 gtt qday
Xopenex
levalbuterol
Zestril
lisinopril
Yaz
drospirenone and ethinyl estradiol
Zoloft
sertraline
Zyloprim
Allopurinol
Zyprexa
olnazapine
Aviane
ethinyl estradiol, desogestrel
ethinyl estradiol, levonorgestrel
Ortho tri cyclin
norgestimate/EE