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80 Cards in this Set

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procaine---duration
short
chloroprocaine---duration
short
lidocaine---duration
intermediate
most common
prilocaine---duration
intermediate
mepivicaine---duration
intermediate
tetracaine---duration
long
bupivicaine---duration
long
most toxic
procaine---onset
long
tetracaine---onset
long
chloroprocaine---onset
short
lidocaine---onset
quick
prilocaine----onset
quick
mepivicaine---onset
quick
articaine---onset
quick
locals used on mucous membrane
benzocaine, lidocaine, cocaine
3 of them
propofol-mode of action
stimulation of GABA
propofol- dose
1-2.5 mg/kg IV

50-200 mcg/kg/min
propofol-onset and duration
onset=30-60 seconds

duration=4-10 minutes
ketamine-mode of action
NMDA
ketamine-dose
1-2 mg/kg IV

5-10 mg/kg IM
ketamine-duration and onset
onset=1-2 minutes IV
onset-5 minutes IM
duration=10-15 minutes
ketamine-metabolism
hepatic
thiopental-mode of action
Barb. that activates GABA receptor and depresses RAS
thiopental-side effects
histamine release
contra in Acute Int Porphyria
thiopental-dose
3-6 mg/kg IV
thiopental-onset and ruration
onset=30 seconds

duration=15-20 minutes
etomidate-mode of action
mimics GABA
etomidate-usage
very cardiac stable
etomidate-side effect
myoclonic movements
etomidate-dose
0.2-0.4 mg/kg IV
etomidate-onset and duration
onset=1 minute

duration=5-15 minutes
etomidate-metabolism
plasma esterase and hepatic microsomal with renal excr.
rocuronium-LOA
intermediate NMB
rocuronium-dose
0.6-1.0 mg IV

1.2 mg/kg IV for RSI
rocuronium-onset and duration
onset=1-2 minutes

dur=30-45 minutes
vecuronium-loa
intermediate NMB
vecuronium-dilution
with preservative free water
vecuronium-dose
.08-.2 mg/kg IV
vecuronium-onset and duration
onset=2 minutes

dur=40-60 minutes
pancuronium-loa
long acting 60-90 minutes
pancuronium-side effect
moderate tachycardia due to antimuscarinic stimulation and increase in BP
pancuronium-dose
.08-.12 mg/kg
pancuronium-onset
1-2 minute, peak 2-4 minutes
aminosteroid NMB
panc, roc, vec
benzylisoquinoline NMB
miv, atrac, cisatrac

histamine release. hoffman elim
mivacurium-dose
.15-.25mg/kg
mivacurium-onset and dur
onset 2 minutes

dur=20-30 minutes
atracrium-loa
intermediate

35-50 minutes
atracrium-metabolite
laudanosine-can produce seizure activity
atracrium-dose
.3-.6 mg/kg
atracrium-onset and dur
onset=2-3 minutes

dur=35-50 minutes
cisatracrium-loa
intermediate/long

40-70 minutes
cisatracrium-use
good for long procedures
miminal histamine release
low laudonasine
no BP or HR change
cisatracrium-dose
.15-.2 mg/kg
cisatracrium-onset and dur
onset=2-3 minutes

dur=40-70 minutes
succ-mech of action
depolarizer, Ach receptor agonist. mimics Ach. allows Na/Ca influx and K efflux
succ-use
RSI

break larngospasm 20mg IV
succ-warnings
high K
burns
denervated from stroke-wait 2 years.
phase II block with repeat dose.
increase IOP, ICP,
can cause MH
succ-metabolism
plasma cholinesterase
succ-dose
1-1.5 mg/kg
2-3 mg/kg children
4-5 mg/kg IM
succ-onset and duration
onset=30 seconds

dur=4-10 minutes
NMB reversal agents
only reverse nondepolarizers

acetylcholinesterase inhibitors, cholinesterase inhibitors, anticholinesterase
goal of NMB reversal
maximize nicotinic transmission and minimize muscarinic side effects
side effects of NMB reversals
SLUD.
increased secretions
bradycardia
neostigmine-mix with ?
.2 mg glycoprolate per 1 mg of neo
neostigmine-dose
.04-.08 mg/kg

max 5 mg
neostigmine-metabolism
hepatic
neostigmine-tx for ?
my. gravis
neostigmine-onset and duration
onset=5-10 minute
peak 10 minute
dur=45-60 minnutes
edrophonium-mix with ?
.014 mg atropine per 1 mg of edrophonium
edrophonium-use
reverses short acting NMB
edrophonium-dose
.5-1 mg/kg
edrophonium-onset and dur
onset=1-2 minutes

dur=5-20 minutes
pyridostigmine-dose
10-20 mg with .6-1.2 mg Atrop
physistigmine-uses
crosses BBB
tx of Atropine intox
exacerbates Parkinsonian sympt
3 of them
physo-onset and dur
onset=3-5 minutes

dur=30 min to 5 hours
factors that delay reversal agent effectiveness
hypothermia
profound block
resp acidosis
certain antibiotics
hypokalemia
hypomagnesium
atropine-mech of action
competetive acetylcholine antagonist at central and peripheral muscarinic receptors
atropine-contraind.
narrow angle glaucoma
causes mydriasis
mydriasis
dilation of pupil