Use LEFT and RIGHT arrow keys to navigate between flashcards;
Use UP and DOWN arrow keys to flip the card;
H to show hint;
A reads text to speech;
10 Cards in this Set
- Front
- Back
- 3rd side (hint)
Ferrous Sulfate
1. Brand name 2. Dosage forms? |
1. Slow FE
FeSO4 |
2. Tab immediate release 325mg ferrous sulfate provides 65mg Fe
Tab ER (Slow FE): 160mg dried ferrous sulfate provides 50mg Fe Some also list 324mg. |
|
Ferrous Sulfate
1. Category? 2. FDA indications/dosage |
Blood modifier
|
2. Tx of IDA:
usual therapeutic dose of Fe is 200mg per day (2-3mg per kg body weight). - Start tx at low dose, titrate up to minimize SE. - Ferrous sulfate immediate release tabs should be given at fasting state to maximize absorption - ER tabs should be given c food |
|
Ferrous Sulfate
1. Pharmacology 2. Pharmacokinetics |
1. Fe is essential for normal erythropoiesis
- Fe deficiency in humans can lead o low Hgb and hypochromic anemia - Can result from inade. intake, interference of iron absorption or from loss of blood. -2/3 of Fe in body is found in Hgb and myoglobin; the rest is stored in ferritin |
- Normal dietary Fe of 14mg/day --> absorption of 1mg/day.
-Absorption through duodenum and upper small intestine -Foods high in Fe = liver, heart, wheat germ, egg yolks, oysters, dried beans and fruit. |
|
Ferrous Sulfate
1. Drug Interactions 2. Contraindications/precautions |
Antacids decrease absorption of iron. Fe decreases absorption of tetracyclines, quinolones, and levodopa
|
2. use with caution in nursing mothers. No nursing category established.
|
|
Ferrous Sulfate
1. Adverse effects 2. Pt Consultation |
1. most common incl: constipation, nausea, vomiting, heartburn, diarrhea
|
2. Immediate release should be taken on an empty stomach; but take c food if GI upset occurs
- ER are taken c food - store in cool dry place away from sunlight & children -contact MD if SE are severe or persistent - if a dose is missed, take it as soon as possible and return to normal dosing. |
|
Vitamin D, Ergocalciferol
1. Brand name 2. Dosage form |
1. Drisdol
|
2. Capsule: each softgel contains 1.25mg in vegetable oil (50,000IU of VitD)
Drops: 200IU of ergocalciferol per drop (8,000 IU per mL) |
|
Vitamin D, Ergocalciferol
1. FDA indications/dosages 2. non-FDA approved indications |
1. For tx of refractory rickets (Vit D resistant rickets): 12000 - 500,000 IU daily.
- Tx of hypoparathyroidism: 50,000 to 200,000IU daily concomitantly w/ calcium lactate 4gm, 6x/day |
2. For tx of Vit D deficiency in adults (25-hydroxyvitamin D3 <20ng/ml)
give 50,000 IU weekly for 8 weeks w/ supplemental calcium followed by 1,000 IU daily w/ suppl calcium |
|
Vitamin D, Ergocalciferol
1. Pharmacology 2. Kinetics |
UV light converts 7-dehydrocholesterol in the skin to cholecalciferol (Vit D3). Both cholecalciferol and ergocalciferol (VitD2) are converted in liver to 25-hydroxyvitamin D forms then in the kidney to 1,25-dihydroxyvit D forms. D2 and D3 are essential for the proper regulation of calcium in plasma and activity of PTH.
|
2. Vit D is involved in the absorption of calcium and phosphorous from small intestine -- provides Ca and P in the plasma to promote bone mineralization. Ergocalciferol is effective in treating hypocalecemia and hyperphosphatemia seen in hypoPTH
|
|
Vitamin D, Ergocalciferol
1. Drug interactions 2. contraindications/precautions |
1. mineral oil interferes w/ absorption of fat soluble vitamins (ie VIt D). Addition of thiazide diuretics to hypoPTH pt concurrently taking Vitamin D, Ergocalciferol may cause hypercalcemia
|
Contraindicated in pts w/ hypercalcemia, malabsorption syndrome, and hypervitaminosis D. Idiopathic hypercalcemia may be caused by hypersensitivity to vit D. Vit D should be restricted in these cases.
Vitamin D has a narrow therapeutic index - dosage levels must be individualized to prevent toxic effects. Frequent blood calcium levels should be taken. Adequate dietary calcium is necessary for clinical response to Vit D therapy. |
|
Vitamin D, Ergocalciferol
1. AE 2. Pt consulation |
1. therapeutic range is narrow
- toxicity may result in renal function impairment, mental retardation, bone demineralization, calcification of soft tissues, nausea, anorexia, constipation, anemia, weight loss |
2. may be take w/ or w/o food
-closely follow prescribed calcium supplementation -do not exceed prescribed dose -contact MD if above side effects are severe or persist -store in cool dry place away from light or kids -if dose is missed, SKIP it then return to normal schedule |