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26 Cards in this Set
- Front
- Back
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Name 2 common ACE inhibitors
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Ramipril
Lisinopril Enalapril |
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State the mechanism of action of ACE inhibitors
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Inhibits angiotension converting enzyme and formation of angiotensin II. Causes vasodilation, decreases aldosterone secretion and increases cardiac output
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Clinical indications for ACE inhibitors (Name 3)
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Hypertension
Heart failure Post MI Diabetic neuropathy |
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Common side effects of ACE inhibitors
(Name 2) |
Cough
Angioedema Hypotension Taste disturbances |
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What class of drug might cause hyperkalaemia if prescribed alongside an ACE inhibitor
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Potassium sparing diuretics (e.g. Spironolactone)
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What pharmological class of drug is Amlodipine?
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Dihydropyridine calcium channel blocker
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What is the mechanism of action of dihydropyridine calcium channel blockers (Amlodipine, Nifedipine)
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Blocks calcium channels in vascular smooth muscle, causing arteriolar vasodilation and increasing coronary blood flow.
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Name 2 clinical uses for Amlodipine
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Hypertension
Angina |
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Name 3 adverse effects of Calcium channel blockers
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Headache
Oedema Hypotension |
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Name 2 common non-dihydropyridine calcium channel blockers
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Verapamil
Diltiazem |
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State the mechanism of action of Verapamil
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Blocks calcium channels in cardiac tissue and vascular smooth muscle. Produces vasodilation, slows heart rate and conduction.
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Name 2 clinical uses for Verapamil
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Hypertension
Angina SVT |
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Name a common thiazide diuretic
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Bendroflumethiazide
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Give a clinical use of bendroflumethiazide
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Hypertension
Hypertension in pregnancy Kidney stones |
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Name 3 potential side effects of thiazide diuretics
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Hypokalaemia
Metabolic alkalosis Hyperuricaemia - gout Increased insulin requirement |
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Name 2 potential drug interactions of thiazide diuretics
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Decreases excretion of Lithium
Hypokalaemia with corticosteroids |
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Name 2 Angiotensin II receptor antagonists
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Losartan
Candesartan |
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Describe the mechanism of action of Losartan
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Blocks angiotensin II receptors in vascular smooth muscle and the adrenal cortex. Causes vasodilation and decreases aldosterone secretion.
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Name 2 clinical uses of Losartan
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Hypertension
Heart failure Diabetic neuropathy |
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Name 2 common anti-anginal agents
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Glyceryl trinitrate
Isosorbide mononitrate |
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Describe the mechanism of action of GTN
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Releases NO in vascular smooth muscle causing vasodilation and increasing coronary blood flow.
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Name 2 clinical uses of GTN
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Angina
Acute treatment of heart failure |
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Name 2 adverse side effects of GTN
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Headache
Hypotension Syncope Reflex tachycardia |
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Name 2 Beta-blockers
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Atenolol
Propranolol |
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Name a common side effect of Beta-blockers
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Postural hypotension
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Name a contra-indication to prescribing Beta-blockers
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Asthma
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