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10 Cards in this Set
- Front
- Back
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EtOH dose-dependent acute central effects
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-100-300 mg/dL (.1-.3%) : cerebellar effects, ie incoordination
-300-400: midbrain - temp regulation, spinal reflexes -450-600: respiratory center depression (cause of death, coupled with aspiration of vomit) |
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EtOH MOA
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-"fluidizes" membranes and affects the membrane components
-potentiates GABA-A inhibition, like other non-selective CNS depressents -may even affect other NT - Receptor systems |
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how do EtOH pharmacokinetics relate to [EtOH]blood?
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zero order elimination, due to the quickly saturable levels of NAD+.
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disulfiram MOA?
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inhibits aldehyde dehydrogenase, potentiating hangover. also inhibits Dopamine Beta Hydroxylase, thus emptying NE stores, leading to hypotension
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why are effects on men/women different?
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same size woman has a smaller volume of distribution than a man. thus her EtOH will be more concentrated
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EtOH effects on organs besides CNS?
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-liver: increases FG - fatty liver
-Kidney - inhibits vasopressin (ADH) release - diuresis -CV - cutaneous dilation - heat loss -Heart - dilated cardiomyopathy |
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possible drug interactions with EtOH?
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-competes w/ drugs oxidized by microsomial system (warfarin, phenytoin, barbiturates - these are oxidized 100% by microsomal system)
-pt on MAOi's - tyramine, from wine, can potentiate effects due to NE and lead to rapid HTN |
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what does an ethanol blood % mean?
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% * 1000 = mg/dL, so 80mg/dL blood = 0.08%
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how does EtOH's actions compare to other non-selective CNS depressents?
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less potent, but same idea - as dose increases, you move from disinhibition - sedation - hypnosis - ataxia - coma - death
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3 ways of EtOH metabolism
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1. ADH then Aldehyde Dehydrogenase, w/ NAD+ for both
2. Microsomal EtOH Oxidizing System 3. Catalases |
