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19 Cards in this Set
- Front
- Back
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Famotidine
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H2 blocker to stop parietal cell HCl secretion
(-tidine = H2 blocker) |
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Nizatidine
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H2 blocker to stop parietal cell HCl secretion
(-tidine = H2 blocker) |
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Cimetidine mech and toxicities (4)
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H2 blocker
potent p450 inhibitor penetrates CNS (dizziness, confusion, headache) antiandrogenic effects decreases renal excretion of creatinine |
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ranitidine mech and toxicity
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H2 blocker
decreases renal excretion of creatinine |
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lansoprazole
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like omeprazole
PPI - inhibits Na/K ATPase in stomach parietal cells |
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Sucralfate clinical applications (2) and mech
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bind to ulcer base and make physical protective barrier
ulcers, traveler's diarrhea |
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Triple therapy for H. Pylori
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bismuth, metronidazole, amoxicillin or tetracycline
can add PPI |
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Misoprostol application in GI
toxicity, contraindication |
is a PGE1 analog, so helps prevent peptic ulcers by increasing protective barrier
toxicity- diarrhea contraindication- pregnancy (can induce abortion) |
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Pirenzepine GI mech, toxicities
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muscarinic antagonist, block actions of ECL cells and parietal cells (rarely used for peptic ulcers)
tachycardia, dry mouth, difficulty focusing eyes |
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Propantheline GI mech, toxicities
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muscarinic antagonist blocks ECL and Parietal cell from making HCl.
tachycardia, difficulty focusing eyes, dry mouth |
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Octreotide clinical applications (4), toxicity
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VIPoma, acromegaly, acute variceal bleed, carcinoid tumors
toxicity- GI distress (nausea, cramps, steatorrhea) |
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which antacid can cause constipation, hypophosphatemia, proximal muscle weakness and seizures
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Aluminum hydroxide (aluMINIMUM amount of feces)
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which antacid can cause diarrhea, hyporeflexia, hypotension, cardiac arrest
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Magnesium hydroxide (Mg Must go to the bathroom)
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which antacid can cause hypercalcemia, rebound acid secretion
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Calcium carbonate
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all antacids can cause what lab change
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hypokalemia
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Infliximab mech, toxicities
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TNF alpha ab
respiratory infection (TB reactivation),fever, hypotension |
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Sulfasalazine clinical applications (2)
activated how? 2 toxicities |
chron's and Ulcerative Colitis
by colonic bacteria toxicities- reversible OLIGOSPERMIA, sulfonamide toxicities |
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Odansetron mech, clinical application, 2 toxicities
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5-HT3 antagonist (opposite mech as sumatriptan)
powerful anti-emetic (for people on chemo) headache (opposite effect of sumatriptan), constipation (locations of serotonin actions) you will not vomit with ODANSETRON, so your can still GO DANCING |
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Metoclopramide for GI:
mech clinical application toxicity drug interaction with (2) contraindicated in |
D2 receptor antagonist
clinical application- for gastroparesis toxicity- parkinsonian effects drug interaction- digoxin and diabetic agents contraindication- pts. with bowel obstruction |
