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35 Cards in this Set
- Front
- Back
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RA and OA are both chronic, systemic dieases. What two characteristics makes RA different?
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Autoimmune
Inflammatory |
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How does RA usually present itself?
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Presents initially as swolllen and tender joints of hands and/or feet.
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RA is characterized by remissions and ____.
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Exacerbations
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Naturally occuring proteins through which cells of the immune system communicate with each other
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Cytokines
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Proinflammatory or Antiinflammatory?
a. TNF b. sIL-1R(IL-1 receptor antagonist) c. IL-1 d. sTNFR e. IL-4 & IL-10 |
a. pro
b. anti c. pro d. anti e. anti |
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What 4 comorbidities have the greatest impact on morbidity and mortality associated with RA?
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1. CV disease
-Vasculitis, elevated CRP(C-reactive protein) 2. Infections (more common) -Pulmonary infections and Sepsis 3. Malignancy(more common) -Risk of lymphoma, leukemia, and multiple myeloma 4. Osteoporosis -Osteoclast acitivity, medication |
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Do radiographic changes occur early or late in RA?
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Early
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What two pharmacologic therapies help alleviate pain and inflammation but do nothing to protect from further RA damage?
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NSAIDs and Glucocorticoids
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What is PPD and when is it necessary in RA therapy.
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It is tuberculosis skin test and should be given prior to Biologics initiation.
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Can you give Biologics in combination?
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NO. Also hold in the presence of infection since they are hugely immunosuppressant
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Biologics are usually employed when An adequate trial of DMARD therapy has failed. However, when can it be first line?
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First line in severe disease
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A general mediator of inflammation that plays a central role in the sequence of cellular and molecular events underlying the inflammatory response.
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TNF-Tumor Necrosis factor
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Pain, Fatique, Stiffness, Impaired Function, and joint destruction are all related to the binding of this to cell-surface receptors.
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TNF
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