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7 Cards in this Set

  • Front
  • Back
cyclic regimen for woman with uterus
Cyclic therapy:
0.3mg/d CEE or equivalent estrogen and progestin 10-14 days/month
Cyclic progestin = MPA 5mg/d or norethindrone 2.5 mg/d or norgestrel 0.15mg/d
WHI prempro study- what was being tested?

outcomes? (3)
CEE 0.625mg/MPA 2.5mg QD or pbo

cancer- increase in breast
CHD** primary outcome- ppl thought prempro could decrease CHD but there were early instances of CHD + stroke later on
fracture risk
WHI study
STOPPED BECAUSE OF BREAST CANCER

ALSO INCREASED RISK OF DEMENTIA
ARR in WHI
ARR for everythign in WHI was 1%
premarin only- outcomes
premarin only- no increase in CHD, no increase in breast cancer (improved actually)

but increase in everything else (stroke, DVT)
onset of action for antidepressant usage
improvement in 1 week for venlafaxine, paroxetine, gaba
monitoring for HRT- 6 things at baseline

then how often after d you monitor everything?
Pelvic and breast exam, Pap smear, mammography
lipid profile, BP
Unopposed estrogen = endometrial evaluation to rule out hyperplasia or CA
E + P = no endometrial evaluation required


BP- eveyr 2 years
eveyrthing else annually