Therapeutics 1

Front 1

Site of inhibition:
Cell wall synthesis-bactericidal
(2)

Back 1

beta-lactams and glycopeptides

Front 2

Site of inhibition:
Protein synthesis-bacteriostatic (except for 1)
(7)

Back 2

aminoglycosides (bactericidal)
tetracyclines
macrolides
lincosamide
streptogramins
oxazolidinone
lipopeptide

Front 3

Site of inhibition:
Nucleic acid synthesis-bactericidal
(2)

Back 3

fluoroquinolones and lipopetide

Front 4

Site of inhibition:
Metabolic inhibitors-bactericidal
(1)

Back 4

sulfonamides

Front 5

cell wall synthesis inhibitors (2) have what type of action?

Back 5

bactericidal
beta-lactams and glycopeptides

Front 6

protein synthesis inhibition (6 and 1) have what type (s) of action?

Back 6

bacteriostatic and aminoglycosides are bactericidal

Front 7

nucleic acid synthesis inhibitors (2) have what type of action?

Back 7

bactericidal

Front 8

metabolic inhibitors (1) have what type of action?

Back 8

bactericidal

Front 9

name the 6 bacteriostatic drug classes

Back 9

1. tetracyclines
2. macrolides
3. lincosamide
4. streptogramins
5. oxazolidinone
6. lipopeptide

Front 10

4 types of beta lactams (cell wall synthesis inhibitors with bactericidal action)

Back 10

1. penicillins
2. cephalosporins
3. carbapenems
4. monobactams

Front 11

penicillin, cephalosporins, carbepenems and monobactams are all bactericidal agents classified as ________ and inhibit ______________

Back 11

beta lacatms, cell wall synthesis inhibitors

Front 12

what type of agent are the following:
penicillin, cephalosporins, carbapenems, monobactams

Back 12

bactericidal beta lactams

Front 13

site of action for the 4 beta lactams?

Back 13

penicillin binding proteins (PBPs)
inhibit final transpeptidation step of peptidoglycan synthesis

Front 14

two classes of cell wall synthesis inhibitors?

Back 14

beta lactams and glycopeptides

Front 15

vancomycin and bacitracin are bactericidal agents in what drug class

Back 15

glycopeptides

Front 16

vancomycin and bacitracin are glycopeptides that inhibit _____________ and are what type of agents

Back 16

inhibit cell wall synthesis and are bactericidal

Front 17

the 2 glycopeptides (cell wall synthesis inhibitors)

Back 17

vancomycin and bacitracin

Front 18

site of action for the 2 glycopeptides?
**what stage of synthesis do they inhibit?

Back 18

inhibits second stage of cell wall synthesis
vancomycin and bacitracin

Front 19

Site of action:
PBP's-inhibit the final transpeptidation step of peptidoglycan synthesis

Back 19

beta lactams:
penicillins, carbapenems, cephalosporins, monobactams

Front 20

Site of action:
Inhibit the second stage of cell wall synthesis by binding to D-alanyl D-alanine portion

Back 20

glycopeptides:
vancomycin and bacitracin

Front 21

Gentamycin, Tobramycin and Amikacin are all what type of protein synthesis inhibitors?

Back 21

aminoglycosides

Front 22

Gent, tobra and amikacin have what type of action?

Back 22

bactericidal-aminoglycosides

Front 23

name the 3 aminoglycosides (protein synthesis inhibitors)

Back 23

gent, tobra, amikacin

Front 24

What is the main type of action that protein synthesis inhibitors exhibit, except for one?

Back 24

bacteriostatic

Front 25

Site of action:
30S ribosome-stop initiation of translation leading to misreading mRNA

Back 25

aminoglycosides:
gent, tobra, amikacin

Front 26

What is the site of action of aminoglycosides (protein synthesis inhibitors)?

Back 26

30S ribosome-stop initiation of translation

Front 27

name the three tetracycline protein synthesis inhibitors

Back 27

doxycycline, tetracycline, tigecycline

Front 28

What type of action does doxy/tetra/tigecycline have?

Back 28

bacteriostatic-protein synthesis inhibitors

Front 29

Site of action:
30S ribosome-blocks tRNA attachment to ribosome causing no chain elongation

Back 29

tetracycline protein synthesis inhibitors:
tetra/doxy/tigecycline

Front 30

tetra/doxy/tigecycline protein synthesis inhibitors have what site of action?

Back 30

30S ribosome-block tRNA attachment to ribosome
tetracycline-bacteriostatic

Front 31

Name the three macrolides (protein synthesis inhibitors)

Back 31

eryth/clari/azithromycin

Front 32

Eryth/clari/azithromycin are what type of agents and inhibit what?

Back 32

bacteriostatic and inhibit protein synthesis
macrolides

Front 33

Site of action:
50S ribosome-ribosomal initiation complex

Back 33

macrolides: eryth/clari/azithromycin
protein synthesis inhibitors

Front 34

Macrolides (3) have what site of action?

Back 34

50S ribosome-ribosomal initiation complex

Front 35

Lincosamide drug (protein synthesis inhibitor)

Back 35

clindamycin

Front 36

What activity does clindamycin have and what does it inhibit

Back 36

bacteriostatic and inhibits protein synthesis
lincosamide

Front 37

Site of action: similar to macrolides
50S ribosome-ribosomal initiation complex

Back 37

lincosamide-clindamycin, protein synthesis inhibitor

Front 38

Site of action of lincosamides (clindamycin)

Back 38

50S ribosome

Front 39

Name the two streptogramins (protein synthesis inhibitors)

Back 39

quinupristin and dalfopristin

Front 40

quinupristin/dalfopristin have what type of activity and inhibit what?

Back 40

bacteriostatic and inhibit protein synthesis

Front 41

Site of action:
50S ribosome-each distant step in synthesis

Back 41

quinupristin/dalfopristin-streptogramins
protein synthesis inhibitors

Front 42

Quinupristin/Dalfopristin (streptogramins) site of action?

Back 42

50S ribosome

Front 43

What two drug classes (and drugs) have a site of action at the 30S ribosome and are protein synthesis inhibitors?

Back 43

aminoglycosides (gent,tobra,amikacin) and tetracyclines (doxy, tetra, tigecycline)

Front 44

Name the two oxazolidinone protein synthesis inhibitors

Back 44

linezolid and chloramphenicol

Front 45

linezolid and chloramphenicol have what type of action and inhibit what?

Back 45

bacteriostatic and inhibit protein synthesis

Front 46

Site of action:
50S ribosome-initiation of protein synthesis

Back 46

quinupristin/dalfopristin
streptogramins-protein synthesis inhibitors

Front 47

Site of action:
50S ribosome-peptidyl transferase->prevent peptide bond formation

Back 47

linezolid and chloramphenicol

Front 48

site of action for linezolid and chloramphenicol (oxazolidinones)

Back 48

50S ribosome-peptidyl transferase preventing peptide bond formation

Front 49

Lipopeptide protein synthesis inhibitor
*also nucleic acid synthesis inhibitor

Back 49

daptomycin

Front 50

Daptomycin (lipopeptide) has was type of action and inhibits what (2)?

Back 50

bacteriostatic, inhibiting protein synthesis and bactericidal, inhibiting nucleic acid synthesis

Front 51

Site of action:
rapid cell membrane depolarization

Back 51

daptomycin (lipopeptide)
inhibitor of protein synthesis (static) and nucleic acid synthesis (cidal)

Front 52

Site of action of daptomycin (lipopeptide)

Back 52

rapid cell membrane depolarization

Front 53

Two classes of nucleic acid synthesis inhibitors

Back 53

fluoroquinolones and lipopeptides

Front 54

Cipro/moxi/levofloxacin, metronidazole and rifampin are all

Back 54

fluoroquinolones-nucleic acid synthesis inhibitors

Front 55

Fluoroquinolones and Lipopeptide nucleic acid synthesis inhibitors have what type of action

Back 55

bactericidal

Front 56

Site of action:
DNA gyrase and topoisomerase II/IV

Back 56

cipro/moxi/levofloxacin fluoroquinolones
nucleic acid synthesis inhibitors

Front 57

cipro/moxi/levofloxacin fluoroquinolones have what site of action

Back 57

DNA gyrase (G-) and topoisomerase II/IV (G+)

Front 58

Site of action:
DNA damage via ferredoxin

Back 58

metronidazole fluoroquinolone
nucleic acid synthesis inhibitor

Front 59

Site of action of metronidazole fluoroquinolone?

Back 59

DNA damage via ferredoxin

Front 60

Site of action:
RNA polymerase-inhibiting RNA synthesis

Back 60

rifampin fluoroquinolone
nucleic acid synthesis inhibitor

Front 61

Class of metabolic inhibitors

Back 61

sulfonamides

Front 62

Trimethoprim (TMP) sulfonamide has what type of action and inhibits what

Back 62

bactericidal and inhibits metabolism

Front 63

Site of action:
dihydrofolic acid reductase

Back 63

TMP

Front 64

TMP sulfonamide site of action

Back 64

dihydrofolic acid reductase
metabolic inhibitor

Front 65

Sulfamethoxazole (SMX) sulfonamide has what type of action and inhibits what

Back 65

bactericidal and inhibits metabolism

Front 66

Site of action:
dihydropteroate synthase

Back 66

SMX sulfonamide
metabolic inhibitor

Front 67

Site of action of SMX sulfonamide
metabolic inhibitor

Back 67

dihydropteroate synthase