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47 Cards in this Set
- Front
- Back
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what is oligospermia
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sperm count <10million
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what is azoospermia
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lack of sperm
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what is asthenospermia
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low motility of sperm
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what hormonal problem in men can impact fertility
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hypogonadism
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what drugs impact male fertility
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chemotherapy
steroids antihypertensives recreational (marijuana) |
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what are some female factors that cause infertility
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hyperprolactinemia
alterations in body weight excessive athletic activity PCOS |
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what are the characteristic signs of PCOS
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anovulation
insulin resistance hyperandrogenism |
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if a patient has PCOS what are some of the things you may see
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HIGH LH:FSH RATIO
acne hirsutism ovarian cysts amenorrhea/oligomenorrhea |
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what can be given to treat infertility due to PCOS
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clomiphene
clomiphene + metformin |
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what tubal and uterine factors cause female infertility
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pelvic inflammatory disease
endometriosis intrauterine device fibroids |
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what drugs in females can cause infertility
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spironolactone
corticosteroids |
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what volume of semen is needed for semen analysis
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2-5 ml
abstinence for 2-3 days |
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what is the function of FSH
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stimulates ovaries to produce estrogen
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what is the function of LH
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stimulates ovaries to ovulate
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what is the function of Prolactin
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interferes with FSH production if elevated
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what is function of TSH
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increase prolactin production
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what is the drug used to treat oligospermia
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clomiphene citrate
Gonal F |
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what is seen with Ovarian Hyperstimulation Syndrome
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ascites
rapid weight gain rupture of ovarian cysts electrolyte imbalance (hyponatremia, hyperkalemia) hypotension liver/renal dysfunction |
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what do you do once you realize pt has OHSS
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with hold HCG treatment and stop treatment cycle
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how many embroyos may be inserted in a woman that's
<35 35-37 38-40 >40 |
<35 = 2
35-37 = 2-3 38-40 = 4 >40 = 5 |
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what is the MOA of clomiphene citrate
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causes hypothalimus to release GnRH as if there is no estrogen being produced
inhibits negative feedback loop |
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what is the indication of clomiphene citrate
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anovulation with entact HPO axis and endogenous estrogen
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what days of the menstraul cycle is Clomiphene given
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days 5-9
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what is the MOA of Letrozole
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aromatase inhibitor - inhibits the conversion of testosterone into estrogen
NOT FDA APPROVED FOR OVULATION INDUNCTION |
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what is the advantage of Letrozole over Clomiphene citrate
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enhanced endometrial thickness
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what are the Menotropins
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pergonal
humegon repronex menopur |
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what is the indication for Menotropins
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hypothalamic pituitary failure
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what are the properties of Menotropins
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contains FSH/LH and
directly stimulates ovaries |
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what days of menstrual cycle are the menotropins given
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days 3- 4
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what are the Follitropins
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Metrodin
Fertinex Gonal-F Follistim |
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patients with what disease would benefit from Follitropins
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patients with PCOS with elevated LH:FSH ratio
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what day in menstrual cycle are Follitropins given
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days 3-4
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what are the GnRH agonist
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lupron
synarel superfact |
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what are the indications for GnRH agonist
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endometriosis
adjunct to HMG/HCG |
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what is the MOA of GnRH agonist and antagonist
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put you in a menopausal state stopping the production of other hormones for the pituitary
PREVENTION OF LH SURGE |
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when are the GnRH agonist given
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day 21 before the new cycle
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what are the GnRH antagonist
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cetrorelix
ganirelix |
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what day are GnRH antagonist given
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day 7 or 8
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what agents allow better follicular synchronization
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GnRH agonist
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when is hCG used
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after pretreatment with clomiphene or menotropins for ovulation
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when is hCG given
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midcycle (day 15-28)
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Lutropin alfa is what type of agent
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recombinant human LH
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LH values of what are considered hypogonadotropic
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LH < 1.2 IU/L
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what agent can be given to treat hyperprolactinemia
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bromocriptine
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when is progesterone given
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after egg retrieval
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what is the function of progesterone
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development of uterine lining
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patients with allergies to peanuts can't get what dosage form of progesterone
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injectable
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