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31 Cards in this Set

  • Front
  • Back
Ig diversity due to
Gene rearrangements via somatic recombination of vdj via rss and rag

Junctional diversity via TdTenzyme and p/ nucleotides
Function AIDe after bcell activation
Somatic hypermutation

Isotype switching
Bcr on surfacemembrane with?
Igalfa/beta for signal transduction
If no AIDe, then?
No somatic hypermutation and isotype switching

Hyper IgM immunodeficiency
Difference avidity and affinity
Affinity: bindingstrength single site

Avidity: binding strength at multiple sites
Best ig for neutralization
Igg and iga
Best ig for opsonizatioin
Igg1 and igg3
Best ig for opsonizatioin
Igg1 and igg3
Best igg for sensitization of nk cells

Think fcgr3
Igg1 and igg3
Best ig for mast cell sensitization
Ige
Best ig for complement activation
IgM and igg1/3
Best ig for trans epithelium
Iga:di and igm via poly ig receptor
Best ig for placentratrans
Igg and best with igg1
Best ig for placentratrans
Igg and best with igg1
Diversity tcr
Somatic recombination

Junctional diversity
N/p nucleotide TdTez
If absence of RAG?
SCID: both functional b and t cells absent
Exprssion tcr on celsurface requires?
CD3complex eg and ed and zeta via ER

Chromosome 11 and 1(zeta)
Difference tcr/bcr and mhc in binding
Mhc has promiscuous binding specifity
Difference mhc 1 and mhc 2 in antigen binding
Mhc1 binding at peptidefragments end: amino terminus and carboxy (hydrophobic/basic) terminus

8-10 aminoacids long

Mhc2: binding entire length with open endpockets so 13-25 aa long
Mhc1 antignpresentation?
Virusproducts via ribosome degraded by (immuno)proteasome in cytosol (immuno version after nkcell's ifngamma)

Antigenic peptides via TAP to ER
TAP selects mhc1 suitable peptides (8-10aa long)
Location mhc:peptide production for mhc1/2
Mhc1: ER

MHC2: mhc via ER and golgi to fuse with vesicle
Location mhc:peptide production for mhc1/2
Mhc1: ER

MHC2: mhc via ER and golgi to fuse with vesicle
Mhc on chromosome?
Chromosome 6
Diversity mhc due to 2 factors
Gene famillies

Geneticpolymorphism

Intallelic conversion or segmental exchange
Mhc 1 isotypes
Hla-
A,b,c,e,f,g
Hla2 isotpes
Hla d
Mopqr
Mhc balancing selection def?
All selective processes that act to maintain a varity of mhc isoforms n th population
Mhc directional selection?
@ ex. Endemics and favours a mhc isoform
HVGD due to
Alloreaction to allogenic HLA

CAVEAT: mother pregnancy production alloantibodies. Caveat at future transplantation
Beleid HVGD
Hla type selection

Serum check for alloantibodies

Immunosuppressant
6 phases of b cel development
1. Repertoire assembly via gene rearrangment in bone marrow
2. Negative selection in bone martow
3. Positive selection to mature in follicle cia ccl19/21 and ccr7
4. Patrolling
5. Antigen recognition
6. Proliferation