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31 Cards in this Set
- Front
- Back
Ig diversity due to
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Gene rearrangements via somatic recombination of vdj via rss and rag
Junctional diversity via TdTenzyme and p/ nucleotides |
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Function AIDe after bcell activation
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Somatic hypermutation
Isotype switching |
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Bcr on surfacemembrane with?
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Igalfa/beta for signal transduction
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If no AIDe, then?
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No somatic hypermutation and isotype switching
Hyper IgM immunodeficiency |
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Difference avidity and affinity
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Affinity: bindingstrength single site
Avidity: binding strength at multiple sites |
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Best ig for neutralization
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Igg and iga
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Best ig for opsonizatioin
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Igg1 and igg3
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Best ig for opsonizatioin
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Igg1 and igg3
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Best igg for sensitization of nk cells
Think fcgr3 |
Igg1 and igg3
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Best ig for mast cell sensitization
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Ige
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Best ig for complement activation
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IgM and igg1/3
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Best ig for trans epithelium
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Iga:di and igm via poly ig receptor
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Best ig for placentratrans
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Igg and best with igg1
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Best ig for placentratrans
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Igg and best with igg1
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Diversity tcr
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Somatic recombination
Junctional diversity N/p nucleotide TdTez |
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If absence of RAG?
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SCID: both functional b and t cells absent
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Exprssion tcr on celsurface requires?
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CD3complex eg and ed and zeta via ER
Chromosome 11 and 1(zeta) |
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Difference tcr/bcr and mhc in binding
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Mhc has promiscuous binding specifity
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Difference mhc 1 and mhc 2 in antigen binding
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Mhc1 binding at peptidefragments end: amino terminus and carboxy (hydrophobic/basic) terminus
8-10 aminoacids long Mhc2: binding entire length with open endpockets so 13-25 aa long |
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Mhc1 antignpresentation?
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Virusproducts via ribosome degraded by (immuno)proteasome in cytosol (immuno version after nkcell's ifngamma)
Antigenic peptides via TAP to ER TAP selects mhc1 suitable peptides (8-10aa long) |
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Location mhc:peptide production for mhc1/2
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Mhc1: ER
MHC2: mhc via ER and golgi to fuse with vesicle |
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Location mhc:peptide production for mhc1/2
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Mhc1: ER
MHC2: mhc via ER and golgi to fuse with vesicle |
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Mhc on chromosome?
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Chromosome 6
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Diversity mhc due to 2 factors
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Gene famillies
Geneticpolymorphism Intallelic conversion or segmental exchange |
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Mhc 1 isotypes
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Hla-
A,b,c,e,f,g |
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Hla2 isotpes
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Hla d
Mopqr |
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Mhc balancing selection def?
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All selective processes that act to maintain a varity of mhc isoforms n th population
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Mhc directional selection?
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@ ex. Endemics and favours a mhc isoform
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HVGD due to
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Alloreaction to allogenic HLA
CAVEAT: mother pregnancy production alloantibodies. Caveat at future transplantation |
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Beleid HVGD
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Hla type selection
Serum check for alloantibodies Immunosuppressant |
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6 phases of b cel development
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1. Repertoire assembly via gene rearrangment in bone marrow
2. Negative selection in bone martow 3. Positive selection to mature in follicle cia ccl19/21 and ccr7 4. Patrolling 5. Antigen recognition 6. Proliferation |