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15 Cards in this Set
- Front
- Back
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What does MHC do?
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controls a set of immunological molecules.
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What is the main importantance for these molecules?
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antigen presentation
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How do ajor histocompatibility antigens mediate graft rejection?
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Activation of allo reactive T and B lymphocytes
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What is GVHD
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Graft vs host disease
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When can GVHD occur
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sevely immunocomromised recipients of graft tissues containing viable hoost leucocytes
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MHC class I antigens are comprised of?
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alpha chain and beta 2 microglobulins
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Where are MHC Class I antigens found?
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all nucleated cells
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MHC class II antigens are compsied of...?
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alpha and beta chains
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Where are MHC Class 2 cells expressed?
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Immune cells
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What family are MHC molecules part of
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Immunoglobulin superfamily
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What are MHC antigens encoded by?
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MHC
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What does MHC comprise?
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Class I, II, III gene regions
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What are the most polymorphic genes in the genome?
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MHC genes
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How are MHC genes inherited?
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co-dominantly
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How are MHC haplotypes inherited?
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en bloc
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