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5 Cards in this Set

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TETRACYCLINES
-Broad spectrum

-Obtained by fermentation with Streptomyces or by chemical transformations of natural products

-Made of 4 annellated 6-member rings
MEDICAL USE: 9 Compounds
TETRACYCLINE
CHLORTETRACYCLINE
METHACYCLINE
ROLITETRACYCLINE
DEMECLOCYCLINE
DOXYCYCLINE
OXYTETRACYCLINE
MECLOCYCLINE
MINOCYCLINE
AMPHOTERIC
-Salts will form with either acids or bases

-In neutral solution, they exist mainly as zwitterions
Salts used?
1)KOH or NaOH- for salts of the acidic enol at C1,2,3. They are very soluble but unstable.
2)HCl- for oral use. Encapsulated bc bitter taste

*Salt solutions must be stabilized with excess acid to prevent crystallization*
DRUG NAME=
TETRACYCLINE