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6 Cards in this Set

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Seminoma
Path: large, uniform cells rather organized; Syncytiotrophoblasts seen in 10% (Corresponds with 10% HCG)

Spermatocytic: older men, usually pure (no concern for mixed) orch and observe

-Most common germ cell tumor; REQUIRES normal AFP is "pure" dx.

- RADIOSENSITIVE
Embryonal
may secrete both AFP & HCG

histo path: WTF? necrosis and hemorrhage
Yolk Sac
may secrete both AFP & HCG

infants and kids

Schiller-Duvall bodies on path

often mets hematogenously
Chorio
Syncytiotrophoblasts & Cytotrophoblasts

NEVER secretes AFP & ALWAYS secretes HCG

often mets hematogenously

can have small testis primary with lots of mets (even wierd places like spleen)

worst prognosis of all
Teratoma
"more than one germ layer in different stages of development" GI tissue, lung,bone,cartilage,squamous,neural tissue

SHOULDN'T SECRETE AFP OR HCG

RESISTANT TO CHEMO/ RADS, REQUIRES SURGERY
Leydig Cell Tumors
Rienke Crystals (cigar shaped)

produce testosterone & 17OH ketosteroids

p/w gynecomastia, low libido, impotence