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28 Cards in this Set
- Front
- Back
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What is the treatment for gonorrhea? |
Ceftriaxone + Azithromycin |
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What is the treatment for Chlamydia? |
Azithromycin 1 g one time |
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What is the treatment for syphilis? |
Benzanthine PCN or for neuro IV PCN G |
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What is the drug used to treat HSV? |
valcyclovir |
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What is the preferred treatment for HIV? (drug classes) |
3 drugs: 2 NRTIs + II or 2NRTIs + PI |
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What is the most common type of resistance in HIV patients? |
M18V: resistance to lamivudine and emtricitabine, GOOD resistance, makes other drugs in combination more effective |
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What is the common NNRTI resistance? |
K103N resistance to efavirinz and nevirapine this is the most common transmitted resistance and is the reason NNRTIs are not in the preferred regimens |
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What mutation causes resistance to all of the NRTIs except zidovudine? |
K65R |
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Name the 5 first line therapies for HIV |
Dolutegravir/Abacavir/lamivudine Dolutegravir + tenofovir/emtricidibine Elvitegravir/cobicistat/tenofovir/emtricidibine Raltegravir + tenofovir/emtricidibine Darunivir + ritonovir + tenofovir/emtricidibine |
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What drug requires and HLAB test before use? |
abacavir |
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What drug combination has an increased risk of MI and hyperlipidemia? |
Abacavir (lopinavir also increased risk of cardiac events) |
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What antiretrovirals should not be used in CD4 count of less than 200 due to high risk of virologic failure? |
rilpavirine darunivir/ritonovir + raltegravir |
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What ART drugs should not be used in an HIV RNA viral load of greater than 100,000 |
rilpavirine Abacavir/lamivudine + efavirinz or atazanavir/ritonavir darunivir/ritonovir + raltegravir |
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If the patient has chronic kidney disease with GFR <60 ml/min what drug do we want to avoid? |
tenofovir |
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What ART drug should be avoided in patients with osteoporosis? |
tenofovir |
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What ART drug should be avoided in patients with psychiatric illness? |
efavirenz |
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What class of drugs have adverse effects on lipids? |
All protease inhibitors |
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What ART drug can cause worsening renal function? |
cobicistat |
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Do we do primary prophylaxis for mucocutaneous candidiasis? |
No |
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What is the main treatment for candidiasis? |
Fluconazole |
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When are patients at risk for pneumocytis pneumonia? |
CD4 count less than 200 or greater than 200 but symptomatic |
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Do we do primary prophylaxis for pneumocystis pneumonia? And if so what is it? |
Yes with TMP/SMX or Dapsone + pyrimethamine +luecovorin
or atovoquone |
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What is the treatment for an active PCP infection? |
TMP/SMX with predisone added in severe disease (PaO2 <70) and prevent recurrence with prophylaxis until CD4 is greater than 200 for 3 months |
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When should prophylaxis be started for Toxoplasmosis? |
CD4 count <100 |
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What is the prophylactic treatment for toxoplasmosis? |
Bactrim |
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What is the TREATMENT for toxo encephalitis? |
Pyrametramine + Sulfadiazine + leucovorin |
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When do we initiate prophylaxis for MAC? |
CD4 <50 |
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What is the prophylactic treatment for MAC and how long? |
Azithromycin or Clarithromycin D/C prophylaxis when CD4 count is above 100 for >3 months |
