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5 Cards in this Set
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- Back
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Angelman Syndrome
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This is a Maternal imprinting disorder, in which the mothers DNA is deleted on Chr. 15q, but the father's DNA is silenced.
symptoms include cognitive delays, ataxia -laughter/happy demeanor ("the happy puppet disorder") |
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Prader-Willi syndrome
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This is a Paternal imprinting disorder, in which the fathers DNA is deleted on Chr. 15q, but the mother's DNA is silenced.
symptoms are extreme hunger, obesity, speech disorder |
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choriocarcinoma
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a malignant tumor of trophoblast cells caused by metatastic trophoblasts cells in uterus.
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Three types of enzymes that facilitate regulation of epigenetic marks
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methyltransferases (Dmnt1, Dmnt3a, Dmnt3b)
methyl binding proteins (MeCP2) histone modifying proteins (HDAC1 - histone deacytlase) - responsible for turning off genes. |
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Vorinostat (trademarked Zolinza) is a drug that is involved in DNA methlyation. What does it do?
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It inhibits histone deacetylases (HDAC), thus making genes that shouldn't be expressed, remain expressed.
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