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62 Cards in this Set
- Front
- Back
TCA cycle occurs in the |
Mitochondria |
|
TCA cycle is a common pathway for |
Carbohydrate, Lipid, and Protein Metabolism |
|
Acetyl CoA used in |
Fatty Acid Biosynthesis, Cholesterol |
|
Enzymes Used in TCA Cycle(8) |
Citrate Synthetase |
|
Citrate Synthetase |
Formation of Citrate from Oxaloacetate and Acetyl CoA |
|
Aconitase |
Citrate to Isocitrate |
|
Isocitrate Dehydrogenase |
Isocitrate to α-ketoglutarate |
|
α-ketoglutarate Dehydrogenase |
α-ketoglutarate to Succinyl CoA |
|
Succinyl CoA Synthetase |
Succinyl CoA to Succinate |
|
Succinyl Dehydrogenase |
Succinate to Fumarate |
|
Any time alkene is formed. ___ is produced |
FADH2 |
|
Fumarase |
Fumarate to Malate |
|
Malate Dehydrogenase |
Malate to Oxaloacetate |
|
All Dehydrogenases produces ____ |
NADH |
|
Sites of TCA cycle Regulation(3) |
Citrate Synthetase |
|
Citrate Synthetase Inhibited by |
ATP, NADH, Citrate |
|
Isocitrate Dehydrogenase Inhibited by |
ATP, NADH |
|
Isocitrate Dehydrogenase Activated by |
ADP |
|
α-Ketoglutarate Dehydrogenase Inhibited by |
ATP |
|
α-ketoglutarate Dehydrogenase Compound takes ______ and makes ____ |
Takes: α-ketoglutarate, NAD+, Acetyl CoA |
|
3 Subunits of the AKDC(Cofactors) |
α-ketoglutarate dehydrogenase(TPP) |
|
2 forms of Arsenic common in poisoning |
Aresnite(AsO2-) |
|
HAsO4 isoelectronic with____and competes with___ |
HPO4- |
|
Bonding of ___ prevents reformation of lipoamide |
Arsenite |
|
Mesaprosol used to treat |
Human African Trypanosomiasis |
|
Oxidative Phosphorylation occurs in |
Inner membrane of mitochondria |
|
Inner Membrane of mitochondria made up of mostly |
proteins |
|
Outer membrane of mitochondria made up of mostly |
phospholipids |
|
PDC, most of TCA, and Beta-Oxidation contained in |
Mitochondrial Matrix |
|
Electron chain _____ the IMM |
polarizes |
|
4 protein Complexes of Electron Transport Chain(type) |
I. NADH-coenzyme Q(oxidoreductase) |
|
Complex I uses ____ to transfer electrons from ____. |
Uses: Ubiquinone |
|
Complex I first transfers electrons to |
FMN |
|
Complex III has ___ as a cofactor |
Cofactor:Iron |
|
Complex IV has __ as a cofactor |
Cofactors: Fe, Cu |
|
Complex II has ___ as a cofactor |
Cofactor:FAD |
|
Complex IV reduces ___ stepwise |
Reduces Oxygen |
|
_____found in mitochondrial space near complex IV |
Superoxide Dismutase |
|
Superoxide Dismutase |
destroys any reactive oxygen species |
|
2 Domains of ATP synthesis and their functions |
F0=cylinder with proton channel |
|
ATP transported from IMM to mitochondrial space by |
ADP-ATP translocase. |
|
Complex I Inhibitors |
Rotenone, Barbituates |
|
Rotenone used for |
head lice, scabies |
|
Complex III inhibitors |
Antimycin A |
|
Antimycin A used a |
topical fungicide, miticide, and insecticide |
|
Complex IV inhibitors |
Molecules that can compete with Oxygen for binding. |
|
2 pathways to transport NADH produced in Glycolysis |
Glycerol Phosphate Shuttle |
|
___pathway loses energy when transporting NADH |
Glycerol Phosphate Shuttle |
|
Glycerol-3-phosphate dehydrogenase |
Dihydroxyacetone Phosphate to Glycerol-3-Phosphate |
|
Glycerol-Phosphate Shuttle carries electrons to complex___ |
II |
|
2 Enzymes involved in Malate-Aspartate Shuttle |
Malate Dehydrogenase |
|
2 pathways to transport NADH produced in Glycolysis |
Glycerol Phosphate Shuttle |
|
___pathway loses energy when transporting NADH |
Glycerol Phosphate Shuttle |
|
Glycerol-3-phosphate dehydrogenase |
Dihydroxyacetone Phosphate to Glycerol-3-Phosphate |
|
Glycerol-Phosphate Shuttle carries electrons to complex___ |
II |
|
2 Enzymes involved in Malate-Aspartate Shuttle |
Malate Dehydrogenase |
|
2 Transporters used in Malate Aspartate Shuttle |
ASP/GLU transporter |
|
In malate-aspartate shuttle, NADH donates its electrons to |
Oxaloacetate |
|
Malate Dehydrogenase |
Oxaloacetate to Malate |
|
Aspartate Aminotransferase |
Oxaloacetate to Aspartate |
|
AKG/Malate transporter |
brings malate into the matrix |
|
ASP/GLU transporter |
brings Glutamate into the matrix |