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20 Cards in this Set
- Front
- Back
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Isoniazid
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Inhibits the synthesis of mycolic acid
TB treatment and prophylaxis Peripheral neuropathy, drug-induced SLE, hepatitis |
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Rifampin
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Inhibits bacterial DNA-dependent RNA polymerase
TB and leprosy treatment Orange urine and hepatitis, induces P450 |
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Ethambutol
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Inhibits arabinosyl transferase
TB treatment Red-green colorblindness, optic neuritis Induces P450 |
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Streptomycin
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Aminoglycoside
Protein synthesis inhibitor TB treatment Ototoxicity |
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Pyrazinamide
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Inhibits fatty acid synthetase I
TB treatment Arthralgia and hepatotoxicity |
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Ethionamide
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Disrupts mycolic acid
TB antibiotic treatment |
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p-aminosalicylic acid (PAS)
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Inhibits nuclear factor-kappa B
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Indinavir
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Protease inhibitor
HIV treatment Kidney stones |
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Nevirapine
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Non-nucleoside RTI
HIV treatment Induces P450 |
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Amphotericin B
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Binds to ergosterol
Broad spectrum antifungal Nephrotoxicity |
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Flucytosine
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Inhibits thymidylate synthetase
Myelosuppression |
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Ketoconazole
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Inhibits ergosterol formation by inhibiting fungal P450 enzymes
Broad spectrum antifungal Gynecomastia, inhibits P450 |
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Fluconazole
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Inhibits ergosterol formation by inhibiting fungal P450 enzymes
Treatment for cryptoccal meningitis and candida sepsis Inhibits P450, no gynecomastia |
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Itraconazole
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Inhibits ergosterol formation by inhibiting fungal P450 enzymes
Treatment for cryptoccal meningitis and candida sepsis Inhibits P450, no gynecomastia |
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Cycloserine
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Inhibits alanine racemase and D-alanine ligase
2nd line antibiotic for TB treatment |
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Zidovudine
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NRTI
megalobastic anemia |
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Didanosine
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NRTI
Pancreatits |
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Saquinavir
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Protease inhibitor
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What are the opportunistic infections in HIV patients with CD4 counts less than 200 cells / microliter?
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Pneumocystitis pneumonia
Cryptococcus neoformans |
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What are the opportunistic infections in HIV patients with CD4 counts less than 50 cells / microliter?
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Histoplasma capsulatum
Coccidioides immitis CMV pneumonitis Mycobacterium avium complex Nontuberculous mycobacterium Aspergillus pneumonia |
