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13 Cards in this Set
- Front
- Back
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difference between bioterrorism and biowarfare?
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warfare - government against target, degrade warfighting.
bioterrorism - political/social objective. terrorize. |
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bacteria in biowarfare/terrorism - which are only in humans, which are only in animals, and which are zoonotic (live in both?
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the pure human ones are:
smallpox cholera shigella animal disease: swine fever, foot/mouth, foul plague, newcastle, rinderpest. everything else is zoonotic. these include ANTHRAX, bruceloosis, cocciodies, VEE/WEE/EEE, ebola/,arkburg, glanders, plague, q fever, rabies, tularemia. |
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compare and contrast biological vs. chemical agents:
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bio:
non-volatile not dermally active odorless/tasteless immunogens aerosol delivery DELAYED ONSET some contageous. CHEMICAL: volatile dermally active odor/taste use mist/droplets/aerosol bad immunogens rapid onset not contagious |
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compare the toxicities of bio toxins vs. chemical agents:
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botulinim toxin is orders of magnitude worse than VX.
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anthrax facts -
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person to person unlikely.
respiratory/cutaneous. natural respiratory is very rare. fatal without treatment. found everywhere, especially texas. humans infected as incidental hosts when in contact with animal skin, bones, hair, etc. 1000+ spores = infectious dose. ON TEST: cutaneous is 95% of cases, 1-5 day incubation, scabs, flu, 1% mortality with treatment, 20% without. if septic = dead ESCHAR. |
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what are the viral threats?
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encephalitis: wee, vee, eee
VHF - viral hemorrhagic fevers: bunyavirus arenavirus filovirus flavivirus (yellow/dengue) Variola - smallpox |
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remind us a bit of the WEE/VEE/EEE. mortality? drugs?
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mosquito transmitted, good as a biowarfare weapon (confusion), good aerosolarized.
get flu like symptoms, photpophobia. worry more about EEE (10-100 virus particles, 90% mortality) WEE/VEE - 1-10 virus particles, 10% mortality. no good drugs, but THERE ARE VACCINES. |
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exam knowledge of VHF's -
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RNA genomes, nature outbreaks with animal/mosquitos,
aerosol = infectious high mortality/morbidity most can be weaponized because of easy culture includes ARENA: lasa, junin, macupo, junin, guanarito, sabia bunyaviruses: rift valley faver, CCHF, hantaviruses. flaviviruses (yellow/dengue) filoviruses |
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specific symptoms to specific diseases?
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junin/machupo - neuro/hemorrhagic
lasa = less hemorrhagic rift valley - retitinitis, little hemorrhagic CCHF = DIC/hemmorhage ebola = macropapular rash/DIC MOST HAVE VACCINES |
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treating VHF?
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rivivarin - supportive care, heparin.
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symptoms of smallpox?
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malaise, back pain, rash (hands/feet/lower extremities, spread to trunk later).
SCABS ALWAYS INFECTIOUS. - urine/blood/etc all bad too. |
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treat smallpox?
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Cidofivir!
Dry-Vax (effective POST EXPOSURE) |
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why not use viruses as bioterror?
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hard to grow and disseminate without hurting yourself. but they're so bad, why not?
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