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7 Cards in this Set
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Pseudomonas Aeruginosa - what does it look like, what does it grow in? Who does it infect?
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Aeruginosa should be a hint that it's an OBLIGATE AEROBE.
it's also a gram negative rod, like the other enterics. it's a big deal in hospitals, can cause just about everything, and tends to infect only those people with immune problems or are otherwise sick. remember that it's green on plates. that's a key word. immediately think about CF patients. premature infants. neutropenic patients. diatbetics. burns. SMELLS LIKE GRAPES (where as staph aureus looks like grapes). |
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what's our clever mnemonic for remembering the things that are risk factors/caused by p. aeruginosa?
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BE PSEUDO -
burns endocarditis pneumonia sepsis external otitis media UTI diabetic osteomyelitis. OSTEOMYELITIS - don't forget that one. |
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what are some lab tests that might indicate something is pseudomonas?
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it's a gram negative rod. but, unlike it's e. coli friends, it's a non-fermenter.
this would put it in the same group as salmonella/shigella. difference here is that it's OXIDASE POSITIVE. note that NEISSERIA is our other oxidase positive fellow. |
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what are the major virulence factors of pseudomonas aeruginosa?
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it's gram negative, so LPS.
pillus, flagllum, ALGINATE and EXOTOXIN A (think aeruginosa = A). note that this not the same thing as LIPID A, present in LPS, though it of course has that too. note that exotoxin A is different from Protein A (in staph aureus) and lipid A (in LPS). |
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what's exotoxin A? what's alginate?
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Same deal as dyptheria toxin - it ADP ribosylates EF-2, stop protein synthesis.
causes serious tissue damage alginate =an adherence factor. think aeruginosa is green and has algae. sticks to respiratory epithelium with algenate, messes with phagocytosis, maybe immunostimulatory. |
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talk about P. areuginosa in CF patients
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it's the major M and M causer. Once the bacteria becomes alginatae positive, it's bad.
colonies on plates that are MUCOID are alginate positive, and the CF patient goes down hill fast. |
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what are the leading causes of otitis media?
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h. influenzae
streptococcus pneumoniae morazella catarrhalis (don't forget the hockey pucks! Hockey Players get MORE ear aches). are 1 2 3 |
