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45 Cards in this Set
- Front
- Back
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Local or systemic: Hystamine
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Local
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Type: Histamine
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Performed
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Location: Histamine
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Mast cells, basophils, platelets
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Action: Histamine
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~Primary triggered for acute inflamation
~Endothelial cells contraction ~Vasodilation ~Causes itchiness |
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Local or systemic: Serotonin
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Local
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Type: Serotonin
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Performed
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Location: Serotonin
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Platelets
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Action: Serotonin
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~similar to histamine - vasodilation
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Location or Systemic: Lysosomal Enzymes
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Local
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Type: Lysosomal Enzymes
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Performed
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Location: Lysosomal Enzymes
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Lysosomes
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Action: Lysosomal Enzymes
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~Degradation of endocytosed molecules
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Local or Systemic: Prostaglandins PGD2
PGE2 PGF2a |
Local
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Type: Prostaglandins PGD2
PGE2 PGF2a |
Newly Synthesized: COX pathway
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Location: Prostaglandins PGD2
PGE2 PGF2a |
?
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Action: Prostaglandins PGD2
PGE2 PGF2a |
~vasodilation
~pain ~Edema |
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Local or systemic: Prostacycline (PG12)
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Local
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Type: Prostacycline (PG12)
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Newly Synthesized: COX pathway
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Location: Prostacycline (PG12)
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Produced in endothelium
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Action: Prostacycline (PG12)
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~Vasodilation
~inhibition of platelet aggregation |
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Drug that Inhibits:Prostacycline (PG12)
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Steroids, COX-1, COX-2 inhibitors, NSAIDs
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Drug that Inhibit: Prostaglandins PGD2 PGE2 PGF2α
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Steroids, COX-1, COX-2 inhibitors, NSAIDs
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Local or Systemic: Thromboxane A2 (TXA2)
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Local
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Type: Thromboxane A2 (TXA2)
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Newly Synthesized: COX pathway (aspirin targets it)
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Location: Thromboxane A2 (TXA2)
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Produced in platelets
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Action: Thromboxane A2 (TXA2)
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~vasoconstriction
~Platelet aggregation |
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Local or systemic: Leukotriene LTB4
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Local
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Type: Leukotriene LTB4
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Newly synthesized: 5-Lipoxygenase pathway
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Location: Leukotriene LTB4
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Produced in neutrophils
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Action: Leukotriene LTB4
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~strong Chemotaxis
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Drug that Inhibit: Leukotriene LTB4
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Steroids, Asthma meds
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Local or Systemic: Leukotriene
LTC4 LTD4 LTE4 |
Local
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Type: Leukotriene
LTC4 LTD4 LTE4 |
Newly synthesized: 5-Lipoxygenase pathway
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Location: Leukotriene
LTC4 LTD4 LTE4 |
Produced by neutrophils
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Action: Leukotriene
LTC4 LTD4 LTE4 |
~Bronchoconstriction
~Vasoconstriction |
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Drug that Inhibit: Leukotriene
LTC4 LTD4 LTE4 |
Steroids, Asthma meds
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Local or Systemic: Lipoxin A4 and B4 LXA4
LXB4 |
Local
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Type: Lipoxin A4 and B4 LXA4
LXB4 |
Newly synthesized: 5-and 12-Lipoxygenase pathway
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Location: Lipoxin A4 and B4 LXA4
LXB4 |
Produced by platelets (with help from neutrophils)
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Action: Lipoxin A4 and B4 LXA4
LXB4 |
~Vasodilation
~Inhibition of chemotaxis ~Monocyte adhesion |
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Drugs that Inhibit: Lipoxin A4 and B4 LXA4
LXB4 |
Steroids
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Local or Systemic: Platelet-Activating factor
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Local
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Type: Platelet-Activating factor
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Newly-synthesized
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Location Platelet-Activating factor
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Produced by almost every cell involved in inflammation
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Action: Platelet-Activating factor
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~Aggregatino and adhesion of platelets
~Vasodilation ~Increased vascular permeability ~Stimulate synthesis of AA metabolites ~Chemotaxis |
