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123 Cards in this Set

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What is follow-up for patients with breast cancer?
Patients should see their physician 2x a year. Annual CXR and LFTs. Patients with lumpectomy should get mammograms of affected breast every 6 months for 2 years and then yearly.
What is the 5 year survivial for stage 1 cancer? Stage 2?
Stage 1 = 93%
Stage 2 = 72%
What is the false negative rate for mammograms?
From 7-20%
Why is surgery necessary for DCIS? What kind of surgery is done?
If lesions remain, the 10 year risk for invasive carcinoma is >30%.
For solitary lesion: lumpectomy and radiation - no need for nodes b/c mets are rare.
Multifocal: Simple mastectomy
What is the treatment for LCIS? Why?
Surveillance with mammograms every 6 months. Its a malignant disease marker with 15-20% 20 year risk of Cancer. There is NO risk of axillary mets.
The most common cause of bloody discharge:
intraductal papilloma - requires surgical biopsy
After the diagnosis of breast cancer, which two tests should be done to detect metastasis?
CXR and LFTs
What is the primary blood supply to the breasts?
Internal mammary and lateral thoracic
This stage breast cancer is >2cm has no nodes and no mets.
Stage I
This stage breast cancer is <2cm with mobile nodes or 2-5cm with no nodes and no mets.
IIA
This stage breast cancer is 2-5cm with mobile nodes or 5+ cm with no nodes and no mets.
IIB
This stage breast cancer is 5+cm with mobile nodes or any size cancer with fixed nodes. May also have skin changes, retraction, and lymphadenopathy.
III
This stage breast cancer has distant mets
IV
What is the standard treatment for stage IV breast cancer?
Palliative radiation and chemo. Surgery may be for debulking.
What is the standard treatment for stage III breast cancer?
Modified radical mastectomy with neoadjuvant therapy (condult radiologist)
What is the 5 year survival for stage 3 breast cancer? Stage 4?
Stage 3 = 41%
Stage 4 = 18%
What are the risks of a core needle biopsy of the breast?
Pneumothorax, hematoma, and has a 20% false negative rate
What are the risks of tamoxifen therapy?
Increased risk of endometrial cancer (1.5%)
Osteoporosis, DVT, menopausal symptoms
What is the treatment for Her2Neu receptor positive Breast CA?
Trastuzumab (Herceptin)
What is Valentino's appy?
Rupture of peptic ulcer that flows down the colic gutters
Name ten things on on the DDX for RLQ pain:
Appendicitis, diverticulitis, TOA, Hepatitis, mesenteric lymphadenitis, gastroenteritis, kidney stone, diverticulitis of cecum, PID, ectopic, UTI, IBD, Pancreatitis and PNA
Describe the clinical appearance of SBO
Patient is distended, air fluid levels seen on KUB, feculent vomit, typanic abd, dehydrated. Metabolic alkalosis with hypo K and hypo CL.
If there is crohn's in the cecum why should you not take out the appendix?
Because it may cause a fistula
Name the 7 causes of a fistula:
FRIENDS: Foreign body, Radiation, Infection, Epitheliazation, Neoplasm, Distal obstruction, Stones
How do you manage a Crohn's SBO?
First with medical management: NPO, bowel rest, TPN and observation. If not improved in 3 weeks, may need to resect affected colon with anastamosis.
How do you manage peri-anal disease with Crohn's?
Drain the peri-rectal abscess and place a seton (hollow plastic tube) in the fistula and give metronidazole
How do you treat mesenteric lymphadenitis?
IVF
How do you treat supperative thrombophlebitis?
Remove the focus on infection (catheter, section of vein), IV antibiotics, consider surgical intervention.
28 year old presents with abdominal pain, elevated WBC and large tubular structure in the retroperitoneum after vaginal delivery:
Suppurative Thrombophlebitis: treat with exploratory celiotomy- find the ovarian vein and excise it
Why should you do an EKG with increased calcium levels?
Can cause short QT intervals with prolonged PR
What is the medical treatment for hypercalcemia?
NS to dilute, diuresis with lasix. Then begin calcitonin, Mithramycin and bisohosphonates.
Name eleven common causes of hypercalcemia:
Hyperparathyroidism, Sarcoidosis, Vitamin A or D intoxication, Iatrogenic (thiazides), Milk alkali syndrome, metastatic cancer, Paget's disease, Addison's disease, neoplasm
Name four ways to test for renal artery stenosis:
Duplex the renal arteries, radioisotope renogram (arteriogram), hypertensive IVP
What test would you do for Cushings?
AM/PM cortisol levels and then a low dose/high dose dexamethasone to confirm (pituitary will have suppression with high dose)
Name five causes of uncontrollable HTN:
1. Cushing's syndrome
2. Renal artery stenosis
3. Conn's syndrome
4. Coactation of the aorta
5. Pheochromocytoma
What test would you do for a pheo?
I-MIBG scan: scintography using iodine- if greater than 5cm = cancer
What is the organ of zuckerandl?
chrommafin body from neural crest cells located at the bifurcation of the abdominal aorta that can be the source of a pheo
What is a pheochromocytoma?
neural endocrine tumor of the adrenal medulla that secretes large amounts of catecholamines (epi and norepi)
What is Conn's syndrome? Why does it cause HTN?
aldosterone producing adenoma. Aldosterone causes the increased exchange of Na+ for K+ in the kidneys leading to hypernatremia and hypokalemia. Na+ retention leads to plasma volume expansion and hypertension:
What ratio would you look at in Conn's syndrome?
Renin: Aldosterone
If this ratio is > 30, this means that there is a lot of aldosterone and not very much renin
Name three imaging tests for Conn's:
1. CT to localize tumor
2. Iodocholesterol scan: scintography of adrenal
3. selective venous sampling of adrenal vein to look for increased aldosterone
How do you treat Conn's?
Spironolactone: it is an aldosterone antagonist
How much does DCIS increase the risk for breast CA?
35X
What two options should be given to women with LCIS?
Close follow up (6 month mammography) or bilateral simple mastectomy
What is the Breslow level?
Gives the five year survival for melaonoma by depth of invasion.
What are the stages of the Breslow levels? What is the 5 year survival?
I : >0.75mm >89% survival
II : 0.75-1.5 75% survival
III : 1.5 - 2.5 58% survival
IV: 2.5-4 46% survival
V: >4mm 25% survival
What tests for mets should be done with a diagnosis of melanoma?
LFTs and CXR
If there is a melanoma of the face, what should be removed?
The melanotic lesion with adequate margins. Do a superficial parotidectomy and modified radical neck dissection. Avoid the marginal mandibular branch of the facial nerve.
What is the Halsted theroy of cancer?
Remove the primary tumor with all lymph node drainage
Change in mental status is due to ________ until proven otherwise:
Hypoxia
What are the two commmon causes of wound infection:
Group D strep and clostridium
An SpO2 of 70, 80, and 90 correspond to a PaO2 of what?
40, 50, and 60. At a PaO2 of 60 the hemoglobin curve drops precipitously
What size tube do you intubate with? Why? Where should it be placed?
Size 8 tube becasue its the smallest a scope will fit down, tip of the tube should be 2cm above the carina, which is about the level of the clavicles.
What is intermittent manditory ventillation?
Has a predetermined rate but patients can breathe over the vent.
What should initial vent settings be?
10-15cc/kg, 10 breaths a min, FiO2 100% and weaned down to <60. PEEP of 5.
Change according to blood gas analysis
What are the benefits and draw-backs of PEEP?
Its good because it keeps pressure in the lungs that keeps alveoli open but is bad because it can cause a PTX, it decreases venous return and cardiac output and can cause hypotension.
If a patient is allergic to heparin but has a PE, what do you do?
Place a greenfield or bird's nest filter in the IVC below the renal arteries.
What is Homan's sign?
A sign of DVT: pain in the calf with dorsiflexsion of the foot while the knee is at 90 degrees
Signs of DVT:
One large leg, Doppler legs, spiral contrast CT of chest
What causes duodeal atresia?
Vascular insult during development that causes failure of recannalization
Why does a child with pyloric stenosis have aciduria?
Due to intractable vomiting, kidneys save Na+ at the expense of H+. They don't exchange it for K+ because K+ is low and they're trying to save that too.
What tests should be done for pyloric stenosis?
U/S or upper GI with barium.
Gastrograffin is water soluble in the peritoneal cavity but causes pneumonitis. Barium is bad in the peritoneal cavity
What causes an inguinal hernia in children?
Patency of the proccussus vaginalis
What is a gastroschisis?
Abdominal wall defect, no surrounding sac, not associated with other anomalies, small defect, diagnosed with prenatal U/S
What is omphalocele?
Abdominal wall defect in which the sac covers extruded viscera, associated with diapgragmatic defect, cardiac problems, pericardium and sternal cleft (Pentalogy of Cantrell)
What pre-op medications are given to a patient undergoing CEA?
Prophylactic antibiotics (foreign body), heparin, and dopamine to keep BP up. Give an alpha blocker pre-operatively and have nitro drip ready for HTN crisis.
Why does a patient have a HTN crisis with CEA?
Carotid body is clamped, body thinks you're hypotensive, releases signal to increase catecholes and blood pressure. Should inhibit carotid body with lidocaine.
Why is a bowel prep important in repair of a AAA?
Because you ligate the IMA which provides blood to watershed areas of the colon (splenic flexure). If there is ischemia of the bowel, patient gets ischemic colitis 2-3 days post-op. Translocation of bacteria will infect the graft.
What preparation is important for a AAA repair:
Get EKG and stress test, do pre-op antibiotics (foreign body) and bowel prep.
What is Dieulafoy's ulcer?
large tortuous ateriole in the stomach that erodes and bleeds and can cause gastric hemorrhage.
What are options for AAA repair?
1. Open repair with direct transabdominal approach
2. Retroperitoneal approach
3. Endograft repair
What is the major drawback of endovascular repair of AAA?
Endoleak: occurs in 20% of patients. Need compliant patient for good followup.
What is an aortoenteric fistula? What causes it?
Fistula between the aorta and duodenum caused by slow growing graft infection with S. epidermidis.
How do you approach fixing an aortoenteric fistula?
Endoscopy in the OR, CT to look for gas bubbles or fluid, take out the infected graft, irrigate with betadine and perfirm exta-anatomic bypass (axillobifem)
How do you prepare a patient pre-op for removal of a pheo?
1. alpha blocker and then beta blocker
2. Intravascular tone will decrease - need swan ganz to measure wedge
3. Type and cross for the 3 adrenal veins
4. pressors, good IVs for fluids
What is MEN1?
Tumos associated with menin gene defect: Pituitary, parathyroid and pancreas
What is Men 2a?
Tumors associated with the Thyroid, parathyroid, and adrenals
Men2b:
Tumors associated with submucosa, medullary thyroid, and adrenal
Why do a trach if patient is on vent for > 2 weeks?
To prevent tracheoinnominate fistula (bracheocephalic artery)
What defibrillator settings are needed for V-fib?
300 and have epi ready. This is for burn patients that may have arrythmias
What should urine OP be in a burn patient?
30cc/hr
Why is myoglobin not good for kidneys? How do you fix this?
It clogs the renal tubules. Flush with isotonic fluids and alkinalize the urine.
Name 6 things to put on burns:
1. Sulfamylon
2. Silvadene
3. Silver Nitrate
4. Bacitracin
4. Betadine
6. Acetic Acid
What are the drawbacks of sulfamylon?
painful- irritates nerve endings
Causes metabolic acidosis because its a CA inhibitor
What are the drawbacks of silvadene?
Transient neutropenia
What are the drawbacks of silver nitrate?
Metabolic alkalosis due to hypo K and hypo Na, turns everything black
Name 6 ways to stop bleeding esophageal varices:
1. sclerotherapy : using sodium morrhuate
2. Balloon tamponade
3. rubber band ligation
4. vasopressin
5. Somatostatin
6. Portocaval shunt
What causes hepatic encephalpathy? How do we test for it?
Its caused by bacteria normally detoxified in the liver
Test for it by measuring arterial ammonia
What are Child's criteria?
Predicts operative mortality in patient's with cirrhosis. Measures ascites, bili, albumin, and encephalopathy
A: no symptoms and no increased risk
B: well controlled ascites, moderate lab values, 15% increase
C: Ascites, encephalopathy, bad nurtrition, 40% mortality
What is TIPS?
transjugular intrahepatic portosystemic shunt: stent placed intrahepatically between the hepatic vein and branch of the portal vein. Is a temporary bridge to transplant
If a mass is detected at the head of the pancreas on CT, how do you biopsy it?
Transduodenal biopsy so that leakage goes into the stomach
Where is the head of the pancreas?
Above the portal vein
Whipple procedure removes what?
distal 1/2 of the stomach (antrum), head of the pancreas, duodenum, gallbladder, cystic duct, common bile duct, proximal jejunum and regional lymph nodes.
Whipple is also a good procedure for what other carcinoma?
Cholangiocarcinoma (5 year survival is 40%)
If pancreatic cancer is unresectable in a patient with symptoms, what can be done?
Relieve biliary obstruction with a stend placed with ERCP.
Stents are frequently infected and need replacement q3 months.
Surgical solution to chronic pancreatitis?
Roux en Y choledochojejunostomy: bypass from the CBD to the jejunum. This prevents alkaline gastritis.
How do you medically treat alkaline gastritis
Cholestyramine to decrease bile acid pool or Calcium to chelate bile acids
What tests should be done to clincally stage colon cancer?
CXR and LFTs and pre-op CEA level
What preparation should be done for a bowel resection for colon cancer?
Check labs, do bowel prep, give antibiotics (neomycin and erythromycin)
What post-op test should be done 6 weeks s/p colon cancer resection?
CEA
Richter's hernia
incarcerated or strangulated hernia involving one side of the bowel
Littre's hernia
hernia involving Meckel's diverticulum
Spigelian hernia
hernia through the linea semilunaris (spontaneous lateral ventral hernia)
Pantaloon hernia:
hernia sac is both direct and indirect and straddles the inferior epigastric vessels
Grynfeltt's hernia
hernia through superior lumbar triangle
Petit's hernia
hernia through inferior lumbar triangle
Bochdalek's hernia
hernia thorugh posterior diaphragm - usually left
Morgagni;s hernia
anterior parasternal diaphragmatic hernia
Cooper's ligament
pectineal line of pelvis
Poupart's ligament
attaches from the ASIS to the pubic tubercle
Nissen
wraps fundus 360 around LES
Belsey Mark IV:
270 degree wrap around the LES
Toupe
180 degree wrap around les
hill repair
posterior gastropexy: uses the arcuate ligament to re-establish the intra-abdominal position of the distal esophagus
Collis-Nissen
cut the stomach to lengthen the esophagus
Heller Myotomy
Used for achasia
Bassini
repair for inguinal hernia, sutures pouparts ligament to the transversus abdominus aponeurosis/conjoint tendon
McVay
Cooper's ligament sutured to transversus abdominis aponeurosis
Wound infection in the first 24 hours is caused by
Group D strep and Clostridium
How do you kill clostridium
PCN
Treatment for acute hyperkalemia
IV calcium is cardioprotective, sodium bicarbonate, glucose and insulin, albuterol, kayexalate, dialysis
Name 6 complications after surgery
1. Death
2. hemorrhage
3. loss of function
4. pain
5. scarring
6. Infection
The biggest risk of giving packed RBCs is _________
bleeding- dilutional effect on platelets