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34 Cards in this Set
- Front
- Back
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True or False: Wound healing cannot be accelerated.
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True
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What are the stops of wound healing?
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homeostasis
inflammation migratory proliferate/collagen synthesis scar remodeling |
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What are the components of homeostasis?
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Platelets
Factor XII Fibrin Fibrin-fibronectin lattice binds cytokines |
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What is the primary component of homeostasis?
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Fibrin
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What happens during inflammation?
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Tissue damage stimulates
Erythema, edema, heat, and pain Monocytes transform into macrophages Both engulf damaged tissue |
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What are the two stages of the Migratory Phase?
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Angiogenesis
Epithelialization |
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When does angiogenesis occur? What happens?
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First 2-3 days
Hypoxic, high lactic acid and low pH Fibrinolysis Budding capillaries join and consolidate |
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When does epithelialization begin? What happens?
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Begins at about 24 hours
Migrate until contact inhibition True rete pegs do not form (basal layer of epidermis?) |
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When does the Proliferative/collagen synthesis begin?
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Day 5 collagen synthesis starts
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How long does collagen content increase?
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3 weeks
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What provided strength in the wound before collagen synthesis?
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Fibrin
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By making collagen incapable of strong crosslinks, what nutritional deficiencies/drugs can compromise the strength of collagen in wound repair?
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Oxygen
Vitamin C Zinc or use of Steroids |
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How much Vitamin a can reverse the affect of steroids in wound repair?
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25,000 IU/day
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Wound contraction happens in what stage?
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Proliferative/collagen synthesis
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When are myofibroblasts most active?
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12-15 days or until edges of the wound meet
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When does scar remodeling happen?
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3 weeks after wounding
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True or False: During scar remodeling, net collagen doubles or triples.
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False: Little net change total wound collagen, but it increases number of crosslinks.
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When does the scar about reach its strongest point?
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at 6 weeks (about 80% of original strength)
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In a skin graft in the first 48 hours, how does it survive?
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serum imbibition
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After a skin graft, when does blood flow become normal?
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7 days
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What are some local causes of wound healing disturbances?
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Infection
Foreign bodies Ischemia/hypoxia Venous Insufficiency Toxins Previous trauma Radiation Cigarette smoking |
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What are some system causes of wound healing disturbances?
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Malnutrition
Cancer Diabetes mellitus Uremia Jaundice Old Age Systemic corticosteroids Chemotherapeutic agents Alcoholism |
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What increases susceptibility for wound infection?
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radiation, impaired circulation, DM, AIDS, uremia, and cancer
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What level of organisms constitute an infection?
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10^5
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True or False: Healing directly correlates with transcutaneous oxygen tension
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True
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Is anemia associated with impaired healing?
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No
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What does irradiation do to cells?
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damages the DNA
decreases vascularity and increases fibrosis increases change of infection |
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In the absence of protein intake, what happens to wound healing?
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collagen synthesis stops
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What nutrition do you need for wound healing?
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Vitamin C, A, D, thiamine, Zince
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True or False: Vitamin E speeds healing?
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False: It impairs wound healing.
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What causes cancer-induced cachexia?
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Decreased caloric intake
Increased energy expenditure |
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What happens if glucose is > 180?
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macrophages don't work
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What is the difference between a hypertrophic scar and a keloid?
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hypertrophic scars are confined to the margins of the original wound.
keloids extend beyond the confines of the wound |
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What are keloids the result of?
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a net increase in collagen.
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