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20 Cards in this Set
- Front
- Back
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Differences between men and women with ALBUMIN
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No gender differences
However albumin is decreased during pregnancy |
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Differences between men and women with ALPHA ACIDIC GLYCOPROTEIN
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Lower in women
Elevated by stress |
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Differences between men and women with SEX HORMONE BINDING GLOBULIN
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Higher in women
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Differences between men and women with LIPOPROTEINS
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Lower in premenopausal women
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Differences between men and women with GASTRIC EMPTYING
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Slower in women
Contributes to IBS |
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Changes during pregnancy with RENAL CLEARANCE
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No gender difference
However renal clearance is increased during prenancy It decreases with age (for men and women) Adjust for body size rather than for gender |
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Changes during pregnancy with DRUG ABSORPTION
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Decreased GI transit time (delayed absoption of oral meds)
Decreased acid secretion (more alkaline) |
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Changes during pregnancy with GALLBLADDER
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Decreased motility
Increased volume |
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Changes during pregnancy with ALKALINE PHOSPHATASE
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4x increase
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Changes during pregnancy with CHOLESTEROL
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Increased
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List two conditions that are related to high estrogen levels and/or liver disfunction
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Spider angiomata
Palmar erythema |
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What changes occur during phase 1 metabolism during pregnancy?
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CYP1A2 decreases (metabs caffeine)
CYP2C9 increases CYP2D6 increases CYP3A4 increases |
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What changes occur during phase 2 metabolism during pregnancy?
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UGT inc's
NAT2 inc's COMT inc's (overall inc in phase 2 metabolism) |
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What changes in acid/base equilibrium occur during pregnancy?
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Mild respiratory alkalosis (7.40 - 7.46)
Dec'd PCO2 (26-32) Dec'd HCO3 (18-21) Left shift of O2 dissociation curve |
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List 6 renal changes that occur during pregnancy
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GFR inc's by 50% (CrCl is 150-200)
Serum Cr is 0.5-0.6 (normal is 0.5-1.0) Inc'd proteinuria Inc'd glycosuria Kindey enlargement (+1cm) Right kidney and/or ureter is dilated |
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What changes occur during pregnancy that affect DRUG DISTRIBUTION?
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Inc'd plasma volume
Inc'd Vd Dec'd plasma protein binding (due to 20-30% dec in albumin during 2nd and 3rd trimester) |
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List the changes in GFR that occur during pregnancy
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1st trimester: Inc's by 50%
2nd trimester: Inc's by 80% 3rd trimester: Dec's back to normal |
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What changes in hepatic blood flow occur during pregnancy?
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Hepatic blood flow inc's during the 2nd trimester
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What changes in peak drug conc occur during pregnancy?
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Peak drug conc dec's due to:
inc'd plasma volume inc'd Vd some decrease due to less albumin and more free drug? |
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What factors contribute to the increased excretion of many drugs during pregnancy?
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Inc'd hepatic metabolism
Inc'd hepatic blood flow Inc'd renal blood flow Inc'd renal GFR |
