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6 Cards in this Set

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Trimethoprim - Sulfamethoxazole
broad G+ and G- uses

inhibits target org. from making nucleic acids and proteins

powerful combo

low chance of resistance
Tri-Sulf uses
UTI
Otitis Media
Bronchitis
PCP pneumonia
GI-shigellosis
Tri-Sulf absorption/distribution
po/IV
well distributed
crosses placenta & in breast milk
*dose based on TMP
*plasma drug levels 1:5 ; double strength used often
*eliminated in urine
Tri-Sulf

adv effects
n/v, rash, allergy, stevens-johnson's, hematologic, kernicterus, crystalluria
(same for sulfonamides)
tri-sulf

drug Ix
intensifies the effect:
coumadin
phenytoin
sulfonylurea-type hypoglycemics

(same for sulfonamides)
trimethoprim
-suppresses DNA/RNA/Protein synth of bacteria
-both bactericidal AND static

AE: well tolerated except rash/itching, GI
**crosses placenta... risk of preg. folate deficiency