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6 Cards in this Set
- Front
- Back
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Trimethoprim - Sulfamethoxazole
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broad G+ and G- uses
inhibits target org. from making nucleic acids and proteins powerful combo low chance of resistance |
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Tri-Sulf uses
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UTI
Otitis Media Bronchitis PCP pneumonia GI-shigellosis |
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Tri-Sulf absorption/distribution
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po/IV
well distributed crosses placenta & in breast milk *dose based on TMP *plasma drug levels 1:5 ; double strength used often *eliminated in urine |
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Tri-Sulf
adv effects |
n/v, rash, allergy, stevens-johnson's, hematologic, kernicterus, crystalluria
(same for sulfonamides) |
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tri-sulf
drug Ix |
intensifies the effect:
coumadin phenytoin sulfonylurea-type hypoglycemics (same for sulfonamides) |
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trimethoprim
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-suppresses DNA/RNA/Protein synth of bacteria
-both bactericidal AND static AE: well tolerated except rash/itching, GI **crosses placenta... risk of preg. folate deficiency |
