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18 Cards in this Set

  • Front
  • Back
Sulfonamides and trimethoprim are _____ spectrum drugs.
How do sulfonamides work?
Block step where PABA is combined with pteridine to form dihydropteroic acid
Competitive inhibitors of the reaction
How does trimethoprim work?
Inhibits dihydrofolate reductase
(Converts dihydrofolate into tetrahydrofolic acid)
Humans and bacteria both need folic acid. How come we are not hurt by taking these drugs?
Human can take in folate from diet; bacteria must synthesize folic acid from precursors
What is the use of sulfonamides?
Urinary Tract Infection
What is the preferred sulfonamide for UTIs?
What are the adverse reactions to sulfonamides?
Stevens-Johnson Syndrome
Hemolytic Anemia
Renal Damage from Crystalluria
What is Stevens-Johnson syndrome?
Wide spread lesions of the skin and mucous membranes with fever, malaise, and toxemia
What should be done if a rash is found while taking sulfonamides?
Discontinue immediately
What is Kernicterus?
Disorder of newborns caused by deposition of bilirubin in the brain
What is bilirubin?
Neurotoxic normally bound to plasma proteins
Who should not receive sulfanomides?
Infants under the age of 2 months or pregnant/breast-feeding women
What can reduce the risk of renal damage from crystalluria?
Maintaining adequate hydration
What is the use of trimethoprim?
Uncomplicated UTIs
What are the adverse effects of trimethoprim?
Hematologic effects
Fetal Damage
Trimethoprim/Sulamethoxazole if sold as a fixed-dose combination product.
T or F
What are the uses of Trimethoprim/Sulamethoxazole?
Pneumocyctis carinii (immunocompromised hosts)
What group of people are especially susceptible to Trimethoprim/Sulamethoxazole toxicity?
AIDS patients