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37 Cards in this Set

  • Front
  • Back
treatment of alcohol withdrawal
treatment of alcohol dependence
disulfiram MOA
antagonizes acetylaldehyde dehydrogenase
disulfiram adverse effects
-metallic after taste
disulfiram patient counseling (4)
1)don't take for at least 12hr after EtOH
2)avoid EtOH in all forms
3)may cause drowsiness
4)EtOH-disulfiram rxn may have serious consequences
Naltrexone place in therapy
-may be effective in reducing number of drinks consumed & craving for alcohol
-may be effective in binge drinkers
naltrexone MOA
long-acting opiod antagonist
naltrexone major adverse effect
hepatotoxicity (check LFTs)
Acamprosate MOA
interacts w/ GABA & glutamate systems
acamprosate adverse effects
depression, anxiety
treatment of opiod intoxication
naloxone MOA
opiod antagonist
treatment of opiod withdrawal
role of clonidine in opiod withdrawal
reduces autonomic symptoms of withdrawal
clonidine MOA
central alpha-2 agonist, which affects the locus ceruleus & spinal cord
clonidine adverse effects
-dry mouth
treatment of opiod dependence
methadone MOA
substitution of long-acting opiod
buprenorphine MOA
partial opiod agonist/antagonist
buprenorphine place in therapy
-less abuse potential--acts as an antagonist at high doses & induces withdrawal
-intended for beginning of opiod dependence treatment
this agent is indicated for maintenance treatment of opiod dependence
treatment of cocaine withdrawal
-no meds have been shown effective in reducing severity
-antipsychotics or BZDs may be helpful if dulusions/paranoia present
treatment of cocaine abuse and dependence
medications are not recommended as first-line therapy
comorbidity with alcohol use:
FM=mood and anxiety d/o
M=personality d/o
laboratory findings in alcohol use
-elevated MCV
-elevated AST,ALT,LDH
-decreased B12, folic acid
-elevated uric acid, amylase
-evidence of bone marrow suppression
treatment of alcohol intoxication
-protective environment
clinical features of alcohol withdrawal
-tachycardia, sweating
-possible szrs
clinical features of alcohol withdrawal delirium (delirium tremens)
-abnormal perceptions
-autonomic instability
Wernicke's encephalopathy triad of clinical features
disulfiram reaction with alcohol
-facial flushing
clinical features of opiod intoxication
-decreased GI motility
-slurred speech
-memory impairment
clinical features of opiod withdrawal
-flu-like syndrome
-disrupted sleep
this agent blunts the euphoric response to heroin
suboxone indication
-not recommended for use during induction period
-initial treatment should begin w/ buprenorphine
-patients whould be switched to this product for maintenance therapy or unsupervised therapy
cocaine intoxication clinical features
-increased BP
-visual/tactile hallucinations
abstinence symptoms of cocaine
phase 1 "crash"=dysphoria, anhedonia, irritability, anxiety, craving, suicidal ideation

phase 2=low level craving, decreased capacity to experience pleasure,
irritability, anxiety
phase 3=mild craving
treatment of cocaine use