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34 Cards in this Set
- Front
- Back
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Fosfomycin MOA
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Cell wall synthesis inhibitor
- blocks first step in petpdoglycan synthesis |
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Fosfomycin - main use?
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- Uncomplicated lower UTI (cystitis)
- Single dose Rx |
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Name 2 major side effects of Linezolid
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BM suppresion (use >2 weeks)
Tyramine cheese reaction (MAO inhibitor) |
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What generation are the following cephalosporins?
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Cefalexin
Cefazolin |
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What generation are the following cephalosporins?
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Cefoperazone
Cefamandole Cefotaxime Ceftriaxone Ceftazidime |
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What generation are the following cephalosporins?
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Cefoxitin
Cefaclor Cefuroxime Cefotetan |
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Which 2 cephalosporins are biliary (NOT renally) excreted
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Cepfoperazone
Ceftriaxone |
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Which cephalosporin causes disulfarim like reaction?
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Cefamandole (contains methylthiotetrazole group)
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Which aminoglycoside is used for treatment of TB, bubonic plague and tularemia?
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Streptomycin
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What group of antibiotics cause blockade at NMJ and enhance muscle relaxants (like botulinum toxin)
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Aminoglycosides
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Name 8 organisms killed by tetracyclines?
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Vibrio cholera
Acne (Proprionibacterium) Chlamydia Ureaplasma Mycoplasma pneumoniae Tularemia H. Pylori Borrelia Rickettsia |
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What 2 classes of antibiotics should not be taken with antacids?
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- Tetracyclines (divalent cations decrease absorption)
- Floroquinolones |
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What is the drug of chioce for Bacillus Anthracis?
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Floroquinolones
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Name 2 first generation sulfonylureas
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Tolbutamide
Chloropromide |
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Which classes of diabetes drugs cause hypoglycemia?
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Insulin
Sulfonylurea Pramlinitide (mimetic decreases glucagon) |
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What drug is a GLP-1 mimetic and increases insulin and decreases glucagon release
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Exenatide
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Which class of diabetic drugs cause hepatotoxicity?
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Gliatazones (Pioglitazone and Rosiglitazone)
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Name 2 long acting insulins
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Glargine
Detemir |
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Name 2 short acting insulins
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LIspro
Aspart |
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Name 4 intermediate acting insulins
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Regular
NPH Lente Isophane |
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Which class of diabetes drugs causes disulfarim like reaction
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Sulfonylureas
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What drug is used in people with diabetes and sulfa allregy?
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Replinigide
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What 5 diseases is Ocreotide used for?
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Acromegaly
Carcinoid syndrome VIPoma Glucagonoma Gastrinoma |
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What is the MOA of Ocreotide
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Analog of somatostatin (inhibits release of pituitary and GI hormones)
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What is the mechanism of demeclocycline in DI?
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Inhibits cAMP formation and limits ADH actions in tubules
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How does lithium cause diabetes insipidus
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Reduces vasopressin (ADH) V2 receptor stimulation of adenyl cyclase in medullary collecting tubule leading to water and salt loss = polyuria
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What drugs increase ADH release (cause SIADH?)
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Diuretics
Carbamazepine Morphine TCA's |
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What eukaryotic DNA polymerase synthesizes the leading strand?
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Delta
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What eukaryotic DNA polymerase synthesizes the lagging strand?
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Alpha
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What eukaryotic DNA polymerase synthesizes mitochondrial DNA?
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Gamma
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What eukaryotic DNA polymerase is involved in DNA repair?
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Beta and Epsilon
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What direction are RNA primers excised?
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5' to 3' exonuclease of DNA polymerase I
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What direction are errors in DNA replication excised?
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3' to 5' exonuclease of both DNA polymerase I and III
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What bacterial DNA plymerase does DNA repair?
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DNA polymerase II
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